Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Kidney alkaline phosphatase

The site should also be involved in the forward reaction (by the principle of microscopic reversibility). An interesting phenomenon in this connection is the stereoselectivity observed in the preferential hydrolysis of L(+)-phosphomandelate by liver and kidney alkaline phosphatases (191). It is not stated whether the selectivity originates in the binding or in the rate of hydrolysis, but whatever the mechanism it seems there must be a direct interaction between mandelate and the enzyme. [Pg.446]

In 1961 Nisselbaum et al. (N22) concluded that the major portion of serum alkaline phosphatase was osteogenic in origin because approximately 66% of the alkaline phosphatase in the sera of three normal patients was precipitated by antihuman bone phosphatase sera. This percentage was appreciably higher in five cancer patients (two with liver metastases, two with bone metastases, and one with metastases to both liver and bone). However, the antibone pho hatase serum precipitated liver and kidney alkaline phosphatase as effectively as it did bone. The authors were not willing for other reasons to attribute to kidney and liver a role as tissue sources of serum alkaline phosphatase, but favored bone as the major source. Pelichova et al. have extended the work on intestine (P3). [Pg.298]

In analogy with the intestinal and kidney alkaline phosphatase that is... [Pg.318]

B45. Butterworth, P. J., and Moss, D. W., Action of neuraminidase on human kidney alkaline phosphatase. Nature 209, 805-806 (1966). [Pg.351]

V7. Vecerek, B., Kraml, J., Pelichov4, H., StSpAn, J., ChmelAr, M., and Stlpek, S., Phosphatases. II. Changes in the composition of human intestinal and kidney alkaline phosphatase during purification. Collection Czech. Chem. Commun. 30, 3964-3968 (1965). [Pg.369]

Weiss MJ, Ray K, Henthom PS et al (1988) Structure of the human Uver/bone/kidney alkaline phosphatase gene. L Biol Chem 263 12002-12010... [Pg.45]

Matsuura S, Kishi F, Kajii T (1990) Characterization of a 5 -flanking region of the human Kver/bone/kidney alkaline phosphatase gene two kinds of mRNA from a single gene. Biochem Biophys Res Commim 168 993-1000... [Pg.45]

Weiss, M. J., Cole, D. E., Ray, K. et al. (1988) A missense mutation in the human liv-er/bone/kidney alkaline phosphatase gene causing a lethal form of hypophosphatasia. Proc Natl Acad Sci USA 85, 7666-7669. [Pg.674]

Ramadoss, C. S., Selvam, R., Shannugasundaram, K. R., and Shamugasundarum, E. R. B., 1974, Rabbit kidney alkaline phosphatase. Role of sialic acid in the heterogeneity, Experientia 30 982. [Pg.97]

Murine leukemia cells Kidney alkaline phosphatase Transferrin... [Pg.307]

Common carp, Cyprinus carpio 1500-6000 After 14 days, gill and liver histopathology and disrupted alkaline phosphatase activity in serum, heart, liver, and kidneys 19... [Pg.790]

Hydrocephaly decreases in weight of brain, lung, liver, and kidney decreases in liver glycogen, kidney proteins and alkaline phosphatase and disrupted brain DNA and protein metabolism (Kav-lock et al. 1982)... [Pg.1139]

Finally we should briefly mention the purple acid phosphatases, which, unlike the alkaline phosphatases, are able to hydrolyse phosphate esters at acid pH values. Their purple colour is associated with a Tyr to Fe(III) charge transfer band. The mammalian purple acid phosphatase is a dinuclear Fe(II)-Fe(III) enzyme, whereas the dinuclear site in kidney bean purple acid phosphatase (Figure 12.13) has a Zn(II), Fe(III) centre with bridging hydroxide and Asp ligands. It is postulated that the iron centre has a terminal hydroxide ligand, whereas the zinc has an aqua ligand. We do not discuss the mechanism here, but it must be different from the alkaline phosphatase because the reaction proceeds with inversion of configuration at phosphorus. [Pg.207]

Osteomalacia is the condition in which bone becomes demineralised due to deficiency of vitamin D. In this condition parathyroid hormone (PTH) acts on the bone to maintain serum calcium, resulting in demineralisation. Serum calcium is usually normal or slightly low alkaline phosphatase levels are high, reflecting excessive osteoblast activity, and serum phosphate falls as an effect of PTH on the kidney. The same condition in children results in defects in long bone formation, and is termed rickets. [Pg.775]

See other pages where Kidney alkaline phosphatase is mentioned: [Pg.421]    [Pg.426]    [Pg.979]    [Pg.272]    [Pg.273]    [Pg.169]    [Pg.28]    [Pg.332]    [Pg.421]    [Pg.426]    [Pg.979]    [Pg.272]    [Pg.273]    [Pg.169]    [Pg.28]    [Pg.332]    [Pg.191]    [Pg.53]    [Pg.192]    [Pg.505]    [Pg.510]    [Pg.642]    [Pg.678]    [Pg.816]    [Pg.1120]    [Pg.84]    [Pg.97]    [Pg.172]    [Pg.174]    [Pg.103]    [Pg.96]    [Pg.603]    [Pg.78]    [Pg.606]    [Pg.60]    [Pg.61]    [Pg.192]    [Pg.505]    [Pg.510]    [Pg.642]    [Pg.678]    [Pg.816]    [Pg.1120]   
See also in sourсe #XX -- [ Pg.417 , Pg.418 , Pg.419 , Pg.420 , Pg.421 , Pg.446 ]

See also in sourсe #XX -- [ Pg.38 , Pg.50 ]



SEARCH



Alkaline phosphatase

Alkaline phosphatase liver/bone/kidney

Kidney cells, alkaline phosphatase

© 2024 chempedia.info