Khosla, Chaitan

Figure 21-11 Catalytic domains within three polypeptide chains of the modular polyketide synthase that forms 6-deoxyerythronolide B, the aglycone of the widely used antibiotic erythromycin. The domains are labeled as for fatty acid synthases AT, acyltransferase ACP, acyl carrier protein KS, 3-ketoacyl-ACP synthase KR, ketoreductase DH, dehydrase ER, enoylreductase TE, thioesterase. After Pieper et al.338 Courtesy of Chaitan Khosla.

Kosan Biosciences, Inc., Hayward, California Chaitan Khosla... 

Chaitan Khosla Departments of Chemistry and Chemical Engineering, Stanford University, Stanford, California... 

A smart way to employ nature s versatility and millions of years development experience to produce desired small-molecule compounds is presented by Chaitan Khosla from Stanford University. Chaitan, who is founder of Kosan Biosciences, received his PhD at the California Institute of Technology, and has extensively published in Nature and Science. After completing postdoctoral studies at the John limes Centre in the UK, he joined Stanford in 1992, where he is now Professor of Chemistry, Chemical Engineering and Biochemistry. His colleague, Martha Lovato Tse, received her BA in Chemistry from Rice University and completed her PhD at the Scripps Research Institute. She then worked with Professor Khosla at Stanford University and is now... 

Rajesh S. Gokhale, Stuart Y. Tsuji, David E. Cane and Chaitan Khosla, Dissecting and exploiting inteimodular communication in polyketide synthases. Science, 284 (1999), 482-485. 

Chaitan Khosla and Pehr B. Harbury, Modular enzymes, Nature, 409 (2001), 247-252. 

Blaine A. Pfeifer, Suzanne J. Admu aal, Hugo Gramajo, David E. Cane, Chaitan Khosla, Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli, Science, 291 (2001), 1790-1792. 

Chaitan Khosla, Professor, Department of Chemistry, Stanford University, Stanford, CA 94305-5080 USA Email khosla stanford. edu... 

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