Ketocarboxylic acid esters ketones, cyclic

Ketocarboxylic acid esters from cyclic ketones s. 17, 194 Nitric acid... [Pg.69]

Ketocarboxylic acid esters from cyclic ketones... [Pg.51]

P-ketocarboxylic acid esters 43, 727 ketones, cyclic 44, 928 p-ketothiolic acid esters 43, 727 y-lactones 43,215... [Pg.219]

Sodium carbonate Cyclic ketocarboxylic acid esters from N-nitroso-a-oxo-N-heterocyclics Ring expansion of cyclic ketones... [Pg.485]

Cyclic ketones from cyclic -ketocarboxylic acid esters COOR H... [Pg.57]

Ketones from y -ketocarboxylic acid esters with protection of the keto group as cyclic ketal Decarboxylation with cleavage of ketals... [Pg.307]

The butylated /J-ketoester C of Figure 13.26 is not the final synthetic target of the acetoacetic ester synthesis of methyl ketones. In that context, the /J-ketoester C is converted into the corresponding /J-ketocarhoxylic acid via acid-catalyzed hydrolysis (Figure 13.27 for the mechanism, see Figure 6.22). This /i-ketocarboxylic acid is then heated either in the same pot or after isolation to effect decarboxylation. The /f-ketocarboxylic acid decarboxylates via a cyclic six-membered transition state in which three valence electron pairs are shifted at the same time. The reaction product is an enol, which isomerizes immediately to a ketone (to phenyl methyl ketone in the specific example shown). [Pg.544]