Ketocarboxylic acid esters cyclic

P-ketocarboxylic acid esters 43, 727 ketones, cyclic 44, 928 p-ketothiolic acid esters 43, 727 y-lactones 43,215... 

Ketocarboxylic acid esters from cyclic ketones s. 17, 194 Nitric acid... 

Ketocarboxylic acid esters from cyclic ketones... 

Sodium carbonate Cyclic ketocarboxylic acid esters from N-nitroso-a-oxo-N-heterocyclics Ring expansion of cyclic ketones... 

Cyclic ketones from cyclic -ketocarboxylic acid esters COOR H... 

Cyclic j -diketones from ketocarboxylic acid esters. Diethyl a-methyl-a-acetyl-glutarate in dry ether added dropwise with stirring to a suspension of alcohol-free K-ferf-butoxide in dry ether, and refluxed 3 hrs. -> ethyl l-methyl-2,4-dioxocyclohexane-l-carboxylate. Y 70.4%. S. M. Mukherji, R. K. Sharma, and O. P. Vig, Soc. 1958, 4770. 

Ketones from y -ketocarboxylic acid esters with protection of the keto group as cyclic ketal Decarboxylation with cleavage of ketals... 

The butylated /J-ketoester C of Figure 13.26 is not the final synthetic target of the acetoacetic ester synthesis of methyl ketones. In that context, the /J-ketoester C is converted into the corresponding /J-ketocarhoxylic acid via acid-catalyzed hydrolysis (Figure 13.27 for the mechanism, see Figure 6.22). This /i-ketocarboxylic acid is then heated either in the same pot or after isolation to effect decarboxylation. The /f-ketocarboxylic acid decarboxylates via a cyclic six-membered transition state in which three valence electron pairs are shifted at the same time. The reaction product is an enol, which isomerizes immediately to a ketone (to phenyl methyl ketone in the specific example shown). 

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