Ketamine, urinary tract dysfunction

R Urinary tract dysfunction after recreational use of ketamine... 

Urinary tract dysfunction has been associated with recreational use of ketamine [43 ]. It was first described in a series of nine patients, all of whom were daily ketamine users, who presented with severe dys-uria, frequency, urgency, and gross hematuria [44 J. The urine cultures were sterile in all cases. CT scans showed marked thickening of the bladder wall, a small capacity, and perivesicular stranding, consistent with severe inflammation. All had severe ulcerative cystitis. Biopsies in four patients showed epithelial denudation and inflammation with a mild eosinophilic infiltrate. Withdrawal of ketamine, and treatment with pentosan polysulfate, gave symptomatic relief. 

A 26-year-old man, a known ketamine user, collapsed. He had previously had severe urinary tract dysfunction treated with antibiotics [5Z J. A CT scan of the abdomen showed bilateral hydronephrosis and cystoscopy showed a significantly reduced bladder capacity without ureteric obstruction. He was hypotensive, acidotic, and in acute renal failure and... 

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See also in sourсe #XX -- [ , ]

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