Bradycardia ketamine

People trying low dosages report feeling disconnected from normal, everyday realities. Blood pressure and pulse are often elevated hypotension and bradycardia have been observed. "Ketamine has a wide margin of safety, observes Parke-Davis brochure "several instances of unintentional administration of overdoses of Ketalar (up to ten times that usually required) have been followed by prolonged but complete recovery. ... 

The side-effects of reserpine include hypotension, bradycardia and increased gastrointestinal motility and diarrhea (Lloyd et al 1985), all resulting from decreased sympathetic tone and increased parasympathetic tone. The hypotensive effects of reserpine may take days to several weeks to occur but may persist for 1 to 6 weeks after the withdrawal of the dmg. Administration of induction agents, such as xylazine and ketamine, that produce hypotension may be fatal in horses treated with reserpine. 

If ketamine is used as the sole anesthetic in the attempted reduction of a dislocated shoulder joint, its actions will include (A) Analgesia Bradycardia Hypotension Muscle rigidity Respiratory depression... 

The inhalational anaesthetics increase the effects of the neuromuscular blockers to differing extents, but nitrous oxide appears not to interact significantly. Ketamine has been reported to potentiate the effects of atracurium. Propofol does not appear to interact with mivacurium or vecuronium. Xenon is reported not to interact with mivacurium or rocuronium, and has less effect than sevoflurane on vecuronium neuromuscular blockade. Bradycardia has been seen in patients given vecuronium with eto-midate or thiopental. Propofol can cause serious bradycardia if it is given with suxamethonium (succinylcholine) without adequate antimuscarinic premedication, and asystole has been seen when fentanyl, propofol and suxamethonium were given sequentially. 

At anesthetic or analgesic doses, ketamine has a wide margin of safety and has little impact upon cardiovascular and respiratory function even in physiologically compromised populations. Preservation, even stimulation, of blood pressure and pulse rate are seen with high doses of ketamine such changes are minimal when very low doses are given. This pattern contrasts with the hypotension and/or bradycardia often seen... 

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