Bradycardia hypotension

Respiratory and central nervous system depression, nausea, vomiting, constipation, diarrhea, bradycardia, hypotension, syncope, hypersensitivity reactions, headache Same as amobarbital sodium... 

Muscarine, an alkaloid from certain species of mushrooms, is a muscarinic receptor agonist. The compound has toxicologic importance muscarine poisoning will produce all of the effects that are associated with an overdose of ACh (e.g., bronchocon strict ion, bradycardia, hypotension, excessive salivary and respiratory secretion, and sweating). Poisoning by muscarine is treated with atropine. 

Symptoms Soman exposure results in pupil constriction, blurred and dimmed vision, pain in the eyeballs chest tightness, difficulty in breathing sweating, salivation, increased bronchial secretions, bradycardia, hypotension, vomiting and diarrhea, bronchoconstric-tion, and urinary and fecal incontinence. 

J hr postexposure Neurologic paresthesias, reversal of hot and cold sensation, pain, weakness 2-5 days postexposure Cardiovascular bradycardia, hypotension, increase in T wave abnormalities... 

Toxicity Toxicity is characterized by an exaggeration of parasympathomimetic effects which may include the following Headache visual disturbance lacrimation sweating respiratory distress Gl spasm nausea vomiting diarrhea AV block tachycardia bradycardia hypotension hypertension shock mental confusion cardiac arrhythmia tremors. 

Systemic - Bradycardia hypotension flushing breathing difficulties sweating. Carbachol... 

Special risk Use caution in patients with marked vagotonia, bronchial asthma, spastic Gl disturbances, peptic ulcer, pronounced bradycardia/hypotension, recent Ml, epilepsy, parkinsonism, and other disorders that may respond adversely to vagotonic effects. 

Alprostadil JProstaglandin E ] (Prostin VR) [Vasodilator/ Prostaglandin] WARNING Apnea in up to 12% of neonates esp <2 kg at birth Uses Conditions ductus arteriosus blood flow must be maintained sustain puhn/systemic circulation until OR (eg, pulm atresia/stenosis and transposition) Action Vasodilator (ductus arteriosus very sensitive), pit inhibitor Dose 0.05 mcg/kg/min IV to lowest that maintains response Caution [X, -] Contra Neonatal resp distress synd Disp Inj meg SE Cutaneous vasodilation, Sz like activity, jitteriness, T temp, thrombocytopenia, BP may cause apnea Interactions T Effects OF anticoagulants antihypertensives, effects OF cyclosporine EMS Given to newborns in hospital OD May cause apnea, bradycardia, hypotension, and flushing symptomatic and supportive... 

Uses Rapid conversion of AF/artmal fluto Action Class III antiarrhythmic Dose Adults >60 kg. 0.01 mg/kg (max 1 mg) IV inf over 10 min may repeat x 1 <60 kg Use 0.01 mg/kg (ECC 2005 D/C cardioversion preferred) Caution [C, -] Contra w/ class I/III antiarrhythmics (Table VI-7) QTc >440 ms Disp Inj SE Arrhythmias, HA Interactions t Refractory effects W7 amiodarone, disopyra-mide, procainamide, quinidine, sotalol t QT int val W7 antihistamines, antidepressants, erythromycin, phenothiazines, TCAs EMS Use antihistamines w/ caution, may T QT interval OD May cause increased repolarization leading to arrhythmias, bradycardia, hypotension leading to cardiac arrest symptomatic and supportive... 

Quazepam (Doral) [C IV] [Sedative/Hypnotic/ Benzodiazepine] Uses Insomnia Action Benzodiazepine Dose 7.5-15 mg PO hs PRN i in elderly hqjatic failure Caution [X, /-] NA glaucoma Contra PRG, sleep apnea Disp Tabs SE Sedation, hangovCT, somnolence, resp depression Interactions T Effects W/ azole antifungals, cimetidine, digoxin, disulfiram, INH, levodopa, macrolides, neuroleptics, phenytoin, quinolones, SSRIs, verapamil, grapefruit juice, EtOH effects W/carbamazepine, rifampin, rifabutin, tobacco EMS Use caution w/ other benzodiazepines, antihistamines, opioids and verapamil, can T CNS depression concurrent EtOH and grapefruit juice use T CNS depression OD May cause profound CNS depression, confusion, bradycardia, hypotension, and altered reflexes flumazenil can be used as antidote activated charcoal may be effective... 

Bradycardia, hypotension, heart block, AMS, Sz, decreased mesenteric perfusion... 

P-Blockers commonly cause side-effects including bradycardia, hypotension, fatigue and bronchospasm. Overdose can cause fatal cardiogenic shock. Because of the doubtful evidence for efficacy and poor tolerability and safety, their use in anxiety disorders is Hmited. They may have a circumscribed role in the prevention of performance anxiety (Elman et al. 1998). 

Propafenone is contraindicated in the presence of severe or uncontrolled congestive heart failure cardiogenic shock sinoatrial, A-V, and intraventricular disorders of conduction and sinus node dysfunction, such as sick sinus syndrome. Other contraindications include severe bradycardia, hypotension, obstructive pulmonary disease, and hepatic and renal failure. Because of its weak (3-blocking action, propafenone may cause possible dose-related bronchospasm. This problem is greatest in patients who are slow metaboUzers. 

Systemic(greaterthan 1%) Fever, flushing, bradycardia, hypotension, tachycardia, diarrhea Occasional... 

Overdosage may result in cholinergic crisis, characterized by severe nausea, vomiting, diarrhea, increased salivation, diaphoresis, bradycardia, hypotension, flushed skin, stomach pain, respiratory depression, seizures, and paralysis of muscles. 

Overdose may produce profound bradycardia, hypotension, and bronchospasm. 

Ophthalmic overdose may produce bradycardia, hypotension, bronchospasm, and acute cardiac failure. 

Of particular importance in the geriatric patient Due to systemic absorption bradycardia, hypotension, heart failure, dizziness, fatigue, bronchospasm due to topical administration stinging, tearing, blurred vision, light sensitivity/photophobia, dryness, decreased visual acuity... 

Bradycardia, hypotension, iritis, miosis, skin reactions, including erythema, eyelid, pruritus, rash, and vasodilation, and tachycardia have been reported. 

Bradycardia, hypotension, convulsions, dysphagia, nausea, vomiting, diarrhea Rare... 

Although serious adverse reactions to lidocaine are uncommon, high dosage by any route may produce cardiovascular depression, bradycardia, hypotension, arrhythmias, heart block, cardiovascular collapse, and cardiac arrest,... 

Paradoxical CNS excitement and restlessness, slurred speech, tremor, dry mouth, diarrhea, nocturia, impotence, bradycardia, hypotension, syncope... 

Agranulocytosis, megaloblastic anemia, apnea, hypoventilation, bradycardia, hypotension, syncope, hepatic damage, and Stevens-Johnson syndrome occur rarely. 

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