Kentucky reference cigarette

The non-filtered low nicotine University of Kentucky reference cigarette, 1A1, was used for this study. Sham animals were exposed to fresh room air in the same manner as the smoked group. 

The complexity of the composition of particulate phase smoke can be seen in Figure 16.2.2, which shows the chromatogram (TIC) of this material from a 1R4F Kentucky reference cigarette. The smoke condensate was extracted with f-butyl methyl ether and separated on a DB-5 column 60 m long, 0.32 mm i d., 1 p film thickness. The GC used a temperature gradient between 50 C and 300 C. 

Table 16.2.8. Compounds in mainstream cigarette smoke considered [58-61] to have adverse effect on human heaith. The level (complied from several reports) Is Indicated for a 1R4F Kentucky reference cigarette. (SM Indicates small molecules Ps indicates polysaccharides including cellulose, pectins, hemicellulose, etc. Pr indicates protein Ma indicates Maillard polymers.)...

Chen, P. X., Mainstream smoke chemical analyses for 2R4F Kentucky reference cigarette. Beits Tabakforsch Int., 20, 448-458, 2003. 

The overestimations were true for both volatile and tobacco-specific NNAs in MSS and SSS for the Kentucky Reference Cigarette 1R4F MSS data indicated that the levels were 380% high for NPYR and 83%, 38%, 27%, and 19% for NAB, NAT, NNK, and NNN, respectively. Thus, it is probable that many of the previously reported levels of NNAs in MSS and SSS, tabulated in various articles [cf. Adams et al. (31), Hoffmaim and Hecht (1727)] and cited by ERA (1148) and the U.S. Surgeon General (4005, 4009, 4010, 15A57) are incorrect. 

In their study of a new Kentucky Reference Cigarette 2R4F, Chen and Moldoveanu (688) described the quantitation of... 

Bereman, R.D., T. Cheng, Y. Ding, LG. GiUman, P. Rainey, N. Finkle, X. Shi, A. Stinson, and J. Keefer The qnantitative determination of 18 selected polycyclic aromatic hydrocarbons in the mainstream of the Kentucky Reference Cigarette, 2R4F Manuscript, December (2004). 

Bodnar, J.E. and J.N. Schumacher Sidestream smoke composition comparison of 1R4F Kentucky Reference Cigarette and a new cigarette that heats but does not bum tobacco 42nd Tobacco Chemists Research Conference, Program Booklet and Abstracts, Vol. 42, No. 59, 1988, p. 46, see www.rjrtdocs.com 507348636 -8636. 

A chromatogram of vapor phase smoke components from a non-commercial reference cigarette (Kentucky 1R4F) [56] is shown in Figure 16.2.1. The chromatogram does not show the peaks for CO, CO2, HjO, CH4, and C2H6 that are present in smoke. 

The four series of cigarettes involved a total of 98 test cigarettes and about 30 reference (Kentucky Reference IRl) and standard cigarettes, divided almost equally among the four series. 

From the results of a study in which Kentucky reference IRl cigarettes were spiked with increasing levels of chlorogenic acid (the 3-ester of 3,4-dihydroxycinnamic acid with... 

Wagner, K.A., R. Higby, and K. Stutt Puff-by-puff analysis of selected mainstream smoke constituents in the Kentucky Reference 2R4F cigarette Beitr. Tabakforsch. Int. 21 (2005) 273-279. 

Quantitative determination of selected compounds in Kentucky 1R4F Reference Cigarette smoke by multidimensional gas chromatography and selected ion monitoring-mass spectrometry J. 4246. 

Nadkami, R.A. and W.D. Ehmann Determination of hace elements in tobacco products by neuhon activation analysis Proc. 1969 Tob. and Health Workshop, Lexington, Kentucky, Tobacco and Health Research Institute, University of Kentucky, Conf. Rep. No. 1, pp. 47-57. Nadkami, R.A. and W.D. Ehmann Further analyses of University of Kentucky reference and alkaloid series cigarettes by instrumental neutron activation analysis Radiochem. Radioanal. Lett. 4 (1970) 325-335. Nadkami, R.A. and W.D. Ehmann Instrumental neutron activation analysis of tobacco products Proc. Modem Trends in Activation Analysis, Gaithersburg, MD, 1968, National Bureau of Standards (Washington, DC) Publ. No. 312(1969) 190-196. 

---