Karnofsky

Description Karnofsky Scale Karnofsky Scale (%) Zubrod Scale (ECOG) Description ECOG Scale... 

Pinter O, Molnar J, Toth C, et al. Administration of estramustine in response to changes in the prostate-specific antigen and Karnofsky index in the treatment of prostate cancer. In Vivo. 2005 19 ... 

The work of Furnas above described and those of others were reexamined by Lovell and Karnofsky (1943). Their mathematical studies were confined to packings composed of spheres of uniform diameter and made allowance for resistance to heat transfer by conduction within the solids. The equation obtained by Lovell and Karnofsky, without correcting for resistance, is of the form encountered in the design of continuous heat exchangers,... 

Values of Tgx computed by this procedure will conform closely to the theoretical values set forth by Lovell and Karnofsky. 

Kalinski and Pien, 175 Kammermeyer, 360 (see also Ward) Karnofsky (see Lovell)... 

Point 1 is also supported by Coats and Karnofsky (130) and, more importantly, is supported commercially in the filtration extraction process for cottonseed (138-140) in which a slurry of cooked cottonseed flakes and miscella is held for a time before the rich miscella is washed off on a continuous horizontal filter. Some practical and theoretical aspects of the solvent extraction of soybeans are discussed by Myers (141). 

In an operating extraction plant, the objective is to reduce the oil left in the solids to the lowest possible level. In practice, this is desirable however, evidence shows that the last portions of extractable oil in the solids are not oils at all but phos-phatides and other nontriglyceride solutes. Bull and Hopper (133) have reported a phosphatide content of 18.62% in the last 1.1% of solute extracted from a sample of soybean flakes with commercial hexane at 40°C (104°F). Karnofsky reported that a similar fraction had a refining loss of 81.5% (32). 

Dollinger MR, Krakoff IH, Karnofsky DA. Quinacrine (Atabrine) in the treatment of neoplastic effusions. Ann Intern Med 1967 66(2) 249-57. 

One almost plaintive maxim, sometimes termed Karnofsky s law, states that almost any substance may be teratogenic if given in appropriate dose regimens to a genetically susceptible organism at a susceptible stage or stages of embryonic or fetal development. 

Karnofsky, D. Burchenal, J. The Clinical Evaluation of Chemotherapeutic Agents in Cancer. In Evaluation of... 

Chapter 16 Antineoplastic Agents Charles W. Young and David A. Karnofsky Sloan-Kettering Institute, New York, N. Y. 

The presence of other disease states may also affect response to treatment by limiting treatment options. The overall functional status of a patient may be assessed using performance status scales, such as the Karnofsky and Eastern Cooperative Oncology Group scales (Table 124-9). These scales can be used to predict patient tolerance of chemotherapy, as well as to assess the effects of chemotherapy on the patient s level of activity and quality of hfe. In many cancers, performance status at diagnosis is the most important prognostic indicator. 

Weiss, M., Karnofsky, J., Hass, R. and Harvan, D. (1979) in 27th Annual Conference on Mass Spectrometry and Allied Topics, Seattle, p. 270. 

Fisher, B. 1980. Laboratory and clinical research in breast cancer-A personal adventure The David A. Karnofsky Memorial Lecture. Cancer Res. 40 3863-3874. 

Heilman, S. 1994. Karnofsky Memorial Lecture natural history of small breast cancers. J. Clin. Oncol. 12 2229-2234. 

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