Kainate receptor subunits

GRIP, PICK1 and PSD95 also interact with kainate receptor subunits GluR5 and 6. PKC, which binds to PICK1, may phosphorylate these subunits, thereby causing them to anchor more stably at the synapse, a mechanism that could strengthen kainate receptor-mediated transmission. 

The focus of the present chapter is on the AMPA receptor subunits iGluRl-4, but examples taken from studies of the low-affinity kainate receptor subunits iGluR5-7 are also included. 

Schiffer, H. H., Swanson, G. T., and Heinemann, S. F. (1997) Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. Neuron 19,1141-1146. 

Patemain, A. V., Herrera, M. T Nieto, M. A., and Lerma, J. (2000) GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors../. Neurosci. 20, 196-205. 

Huntley, G. W., Rogers, S. W Moran, T Janssen, W., Archin, N., Vickers, J. C et al. (1993) Selective distribution of kainate receptor subunit immunoreactivity in monkey neocortex revealed by a monoclonal antibody that recognizes glutamate receptor subunits GluR5/6/7../. Neurosci. 13, 2965-2981. 

Petralia, R. S., Wang, Y. X., and Wenthold, R. J. (1994) Histological and ultrastructural localization of the kainate receptor subunits, KA2 and GluR6/7, in the rat nervous system using selective antipeptide antibodies. J. Comp. Neurol. 349, 85-110. 

Kerchner, G. A., Wilding, T. J., Huettner, J. E and Zhuo, M. (2002) Kainate receptor subunits underlying presynaptic regulation of neurotransmitter release in the dorsal horn. J. 

Chittajallu R., Braithwaite S. P., Clarke V. R. J., and Henley J. M. (1999). Kainate receptors subunits, synaptic localization and function. Trends Pharmacol. Sci. 20 26-35. 

Jaskolski F., Normand E., Mulle C., and Coussen F. (2005). Differential trafficking of GluR7 kainate receptor subunit splice variants. J. Biol. Chem. 280 22968-22976. 

Contractor A, Swanson GT, Sailer A, O Gorman S, Heinemann SF (2000) Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus. J Neurosci 20 8269-78 Cossart R, Tyzio R, Dinocourt C, Esclapez M, Hirsch JC, Ben-Ari Y, Bernard C (2001) Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal intemeurons. Neuron 29 497... 

Porter RH, Eastwood SL, Harrison PJ. 1997. Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. Brain Res 751 217-231. 

Nanao, M.H., Green, T, Stem-Bach, Y., Heinemann, S.E, and Choe, S. 2005. Stmcture of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid. PNAS 102, 1708-1713. 

Expression of NMDA and high-affinity kainate receptor subunit mRNAs in the adult rat retina. Eur J Neurosci 6 1100-1112. 

Brandstatter JH, Koulen P, Wiissle H (1997) Selective synaptic distribution of kainate receptor subunits in the two plexiform layers of the rat retina. J Neurosci 77 9298-9307. 

TABLE 1. Expression of NMDA, AMPA and kainate receptor subunit mRNAs in selected cell types of the rat central nervous system... 

Fig. 4. (A-J) Distribution of kainate receptor subunit mRNAs in the adult rat brain (X-ray film autoradiographs, coronal sections). Arrowheads in E and F mark neocortical layer III cells expressing the GluR7 gene. AV, anteroventral thalamic nucleus BST, bed nucleus stria terminalis CC, corpus callosum white matter tract Cg. cingulate cortex Cpu, caudate putamen DG, denate granule cells DM, dorsomedial hypothalamic nucleus GP, globus pallidus MPA, medial preoptic area Pir, piriform cortex Rt, reticular thalamic nucleus SCh, suprachiasmatic nucleus. Scale bar, 3.2 mm (Wisden and Seeburg, 1993a).

Fig. 10. The cell types in the rat retina and their expression of the AMPA, NMDA and kainate receptor subunit mRNAs (circuit diagram adapted from Barnstable, 1993 Bahn and Wisden, 1997). The assignment of subunit groupings to different cell classes does not imply that, for example, all amacrine cells co-express all the listed subunits subsets of amacrine cells, horizontal or ganglion cells express different subunit combinations (see text).

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