Jun N-terminal protein kinase

Aggarwal, B. B. (2000). Leflunomide suppresses TNE-induced cellular responses effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. 

The G12 subfamily has been implicated in such cellular processes as reorganization of the cytoskeleton, activation of the c-Jun N-terminal protein kinase (see Section 10.2.2), and stimulation of Na+/ H+ exchange. Activation by thromboxane and thrombin receptors has been described for members of the G12 subfamily. Examples of effector molecules include nucleotide exchange factors for Rho proteins and the GTPase-activat-ing protein Ras-GAP (see Section9.5). 

The first signaling pathway identified to modulate APAP-induced liver injury was c-Jun N-terminal protein kinases (INK) (Gunawan et al. 2006 Henderson et al. 2007 Latchoumycandane et al. 2007). INK are a family of serine/threOTiine kinases... 

Bae MA, Song BJ (2003) Critical role of c-Jun N-terminal protein kinase activation in troglita-zone-induced apoptosis of human HepG2 hepatoma cells. Mol Pharmacol 63(2) 401-408... 

Soh Y, Jeong KS, Lee IJ, Bae MA, Kim YC, Song BJ. Selective activation of the c-Jun N-terminal protein kinase pathway during 4-hydroxynonenal-induced apoptosis of PC12 cells. Mol Pharmacol 2000 58(3) 535-541. 

Yamamoto K, Ichijo H, Korsmeyer SJ. BCL-2 is phosphorylated and inactivated by an ASKl/Jun N-terminal protein kinase pathway normally activated at G(2)/M. 

Guo, Y.L., Baysal, K., Kang, B., Yang, L.J., and Williamson, J.R. 1998. Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells. / Biol Chem 273 4027-4034. 

Benhar, M. et al., Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress, Mol. Cell. Biol., 21, 6913, 2001. 

Shifrin, V. I. and Anderson P. Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J. Biol. Chem. 274, 13985, 1999. 

Okubo, Y., Blakesley, V. A., Stannard, B., Gutkind, S., and LeRoith, D., Insulin-like growth factor 1 inhibits the stress-activated protein kinase—Jun N-terminal kinase. J. Biol. Chem. 273, 25961-25966 (1998). 

W16. Wong, C. K., Zhang, J. P., Lam, C. W. K., Ho, C. Y, and Hjelm, N. M., Sodium salicylate-induced apoptosis of human peripheral blood eosinophils is independent of the activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Int. Arch. Allergy Immunol. 121, 44-52 (2000). 

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