Janowski

Janowsky DS, el-Yousel MK, Davis JM, et al Provocation of schizophrenic symproms by intravenous administration of methylphenidate. Arch Gen Psychiarry 28 185— 191, 1973... 

C. G., Janowski B.A., Corey D. R. Inhibition of gene expression inside cells by peptide nucleic acids effect of mRNA target sequence, mismatched bases, and PNA length. Biochemistry 2001 40 53-64. 

Janowski, M. P. Sesack, S. R. (2004). Prefrontal cortical projections to the rat dorsal raphe nucleus ultrastructural features and association with serotonin and gamma-aminobutyric acid neurons. J. Comp. Neurol. 468, 518-29. 

Two models have been proposed for how this dimeric structure may relate to the structure of cystatin C in the fibril. The first (Janowski et at, 2001) proposes that run-away domain swapping (like that shown in Fig. 11C) can account for the assembly and stability of the fibril. In this model, one monomer would swap /(I-a 1-/12 into a second monomer, the second would swap its /(I-a 1-/12 into a third, and so on. The second model (Staniforth et al., 2001) proposes a direct stacking of domain-swapped dimers, where /i5 of each subunit of the dimer would interact with /(I of a subunit of the adjacent dimer. In this way, the dimers would stack to form continuous /1-sheets. Both models arrange the /(-sheets parallel to the fibril axis with component /(-strands perpendicular to the axis, as in a cross-/ structure, although no diffraction pattern has been reported for cystatin fibrils. 

Janowski, R., Kozak, M., Jankowska, E., Grzonka, Z., Grubb, A., Abrahamson, M., and Jaskolski, M. (2001). Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping. Nat. Struct. Biol. 8, 316-320. 

Nilsson, M., Wang, X., Rodziewicz-Motowidlo, S., Janowski, R., Lindstrom, V., Onnerfjord, P., Westermark, G., Grzonka, Z., Jaskolski, M., and Grubb, A. (2004). Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C Use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin C.J. Biol. Chem. 279, 24236- 24245. 

Janowski, B.A., Grogan, M.J., Jones, S.A., Wisely, G.B., Kliewer, S.A., Corey, E.J. and Mangelsdorf, D.J. (1999) Structural requirements of ligands for the oxysterol liver X receptors LXRa and LXRp. Proceedings of the National Academy of Sciences of the United States of America, 96, 266-271. 

Maynard CL, Harrington LE, Janowski 23 KM, et al Regulatory T cells expressing interleukin 10 develop from Foxp3(-l-) and Foxp3(—) precursor cells in the absence of interleukin 10. 

Simmrock, K. H., R. Janowsky and A. Ohnsorge, CRITICAL DATA OF PURE SUBSTANCES. Vol. II, Parts 1 and 2, Dechema Chemistry Data Series, 6000 Frankfurt/Main, Germany (1986). 

It has been known for a long time that polynitroaromatic compounds produce colored products in contact with aUcafis [1]. These color reactions have been extensively used for the identification of nitroaromatic explosives. In the Janowski reaction [7], a solution of the polynitroaromatic compound (di- or trinitroaromatic) in acetone is treated with concentrated aqueous KOH solution. 1,3,5-Trinitrobenzene (TNB) and 2,4,6-trinitrotoluene (TNT), treated with 30% aqueous KOH, produced violet-red and red colors, respectively. Many variations of the Janowski reaction were reported, using KOH or NaOH in aqueous or ethanoHc solutions as reagents, and dissolving the explosives in acetone, ethanol or acetone-ethanol mixture [3,8]. The reaction was used both for spot tests and for spraying TLC plates [9]. 

A field test for the detection of TNT in contaminated soils (e.g., near ammunition plants) was based on the color reaction between TNT and alkalis (the Janowski reaction [7]) [26]. A few milligrams of the suspected soil are placed on filter paper and sprayed with 1 M NaOH acetone (1 1). A red color indicates the possible presence of TNT. Detection limits were reported to be 2-50 mg of TNT per 1 kg of soil, depending on the type of soil. The same group [55] used the oxidation of DPA in concentrated H2SO4 as the basis of a field test for nitrate esters and nitramines in soil. 

B. A. Janowsky, P. J. Wiley and T. R. Devi, An Oxystyerol-Signalling Pathway, Mediated by the Nuclear Factor LXR-alpha, Nature, 1996, 383, 728-31. 

Kelly JX, Smilkstein MJ, Brun R, Wittlin S, Cooper RA, Lane KD, Janowsky A, Johnson RA, Dodean RA, Winter R, Hinrichs DJ, Riscoe MK. (2009) Discovery of dual function acridones as a new antimalarial chemo-type. Nature 459 210-213. 

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