J. T. Baker Company

Scheme 4. The Sharpless asymmetric epoxidation in the J.T. Baker Company s commercial synthesis of (7/ ,8S)-disparlure (15).

Acetic acid (100%) was purchased from J. T. Baker Company and was used as received. 

The term solid-phase extraction was introduced by personnel of the J. T. Baker Company in 1982. The method consists of retention of the analytes from a liquid or gaseous sample to a solid stationary phase and subsequent removal of analytes using an appropriate eluent. The main purpose of SPE is isolation and preconcentration of compounds of interest or sample clean-up and simplification of the matrix. Application of this sample preparation technique also allows extract fractionation. As a result of significant reduction in the volume of organic solvents used, high recovery, and the possibility of process automation, SPE is a good alternative for conventional liquid-liquid extraction. According to their affinity for the compound of interest, stationary phases are classified as follows ... 

Perchloric acid (70%) was obtained from J. T. Baker Company. Reaction of 70% perchloric acid with organic materials can lead to fires and explosions, and anhydrous HCIO is potentially explosive. Although no incidents occurred in the experience of the submitters, care should be taken in handling this compound. 

For washcoat preparation silicalite zeolite powder (S-115 from Union Carbide Corp.) was dried at 100°C in an oven overnight. Prehydrolyzed ethyl-orthosilicate containing 19.52 silica (Silbond H-5 from Stauffer Chemical Co.) was the source of the silica binder. Absolute ethanol (from U.S. Industrial Chemicals Co.) and absolute methanol (reagent grade from J. T. Baker Company) were used without further purification for the liquid portion of the washcoat slurry and for the methanol conversion reaction, respectively. Reagent grade ammonium nitrate (from J. T. Baker) was used for ion-exchange purposes. 

Whereas primary aUyl alcohols may be converted to the extent of 100%, for secondary alcohols, kinetic resolution is used to obtain one diastereomer in excess. The J. T. Baker Company harked back to the original work of Sharpless [194] and developed from it an industrial process for the production of (+)-dis-parlure. 

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