Minocycline Isotretinoin

Clinically important, potentially hazardous interactions with acitretin, bexarotene, fish oil supplements, isotretinoin, minocycline, prednisone, tetracycline, warfarin... 

Corticosteroids TetracycUnes (including minocycline, doxycycUne) Nitrofurantoin NaUdixic acid Vitamin A (retinoids, including isotretinoin) Oral contraceptives... 

Clinically important, potentially hazardous interactions with alcohol, bexarotene, chloroquine, cholestyramine, corticosteroids, danazol, ethanolamine, isotretinoin, lithium, medroxyprogesterone, methotrexate, minocycline, progestins,... 

Numerous drugs have been associated with the development of vasculitis (ten Holder et al. 2002 Cuellar 2002). For example propylthiouracil is associated with cutaneous, renal, and pulmonary vascultis aUopurinol is associated with cutaneous, renal, and hepatic vasculitis hydralazine is associated with cutaneous, renal, and pulmonary vascultis and isotretinoin is associated with cutaneous, renal, pulmonary, and gastrointestinal vascultis (Cuellar 2002 ten Holder et al. 2002). Systemic polyarteritis nodosa, a vasculitis with involvement of small- and mediumsized renal arteries, has been described following minocycline use (Cuellar 2002). Patients may present with hematuria, proteinuria, reduced renal function, and hypertension. Hydralazine, propylthiouracil, aUopurinol, and peniciUamine have been implicated in the development of antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis (Choi et al. 2000). Patients exposed to these drugs... 

After the procedure, the patient is advised to use water-based lotion creams and potent sunscreens. The erythema gradually resolves over about 2-month period. During this time, makeup foundation is encouraged. In dark skin patients (Fitzpatrick skin type 3 or 4), the application of Kligman preparation is recommended to prevent reactive hyperpigmentation. In after-procedural flare-ups, minocycline or systemic isotretinoin are prescribed immediately to avoid new scars creation. 

Oil acne is treated with the usual acne vulgaris modalities, such as topical benzoyl peroxide and retinoic acid. Systemic treatment is often needed with tetracycline, erythromycin or minocycline, or with isotretinoin in severe cases. The key factor is avoiding contact with oils and grease. Work clothes should be changed daily and frequent cleansing of the skin with soap and water is advised. 

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