5-isopropyl-4- thio

Recently, Naskar et al. have used a fourth method, i.e., use of a novel cross-linking agent, bis(di-isopropyl) thio-phosphoryl disulfide, which reacts with both rubbers, thereby linking the two phases intimately and providing a robust blend [29]. The reaction scheme is given in Figure 11.7. 

Methionin (70-a-Methyl- Elbd, 431 (Alkylierung/Hydrolyse) Propansaure /-2-Amino-3-isopropyl-thio- XI/2, 441 Thiocarbamidsaure N-Ethoxy- -S-isopropylester E4, 331 (Cl - NH-OR)... 

Hydrazin (2-Hydroxy-3-isopropyl-thio-propyl)- El6a, 438 (N-Alkyl.)... 

Bernstcinsaure 3-tert.-Butyl-2-(2-pyridylthio)- -dinitril E19a, 1260 [ — CO — O — N + En (intra rad.)] Pyridazine 6-Amino-3-isopropyl-thio-3-phenyl- E9a, 659 (N = PR3 -3 NH2)... 

In contrast to many furan syntheses, this method uses 2-(2-hydroxyalkyl)phenoIs containing a leaving group at the benzylic carbon atom. Thus, 2-(I-isopropyl-thio-2-hydroxy)phenol cyclizes on heating with concentrated hydrochloric acid, but when 2-(2-hydroxyethyl)phenol was similarly treated, cyclization did not occur. When R = H, 2-unsubstituted benzofurans are obtained in good yield minor modifications were made in the synthesis of the 2-phenyl derivatives, and... 

The discovery of the cyclic AMP receptor protein (CAP) in E. coli is most intriguing because it further illustrates the complexities of gene expression even in a relatively uncomplicated system. In E. coli, cyclic AMP stimulates the elaboration of catabolic enzymes involved in the breakdown of arabinose and maltose [184, 185]. A mutant of E. coli has been found that fails to grow on maltose and arabinose. The mutants lack a protein receptor for the cyclic AMP which is believed to bind probably to DNA, but possibly to RNA, which must be present for the induction of the catabolic enzymes. It has also been shown that in order to secure optimal transcription of the lac operon (see below), both the inducer—for example, isopropyl thio-galactoside—and cyclic AMP must be added. 

M IPTG (isopropyl-thio-(3-D-galactopyranoside) stock solution. 

Preparation of 6-azacytidine-5 -phosphate by direct phosphorylation with cyanoethylphosphate was not successful. The substance could be prepared, however, on ammonia treatment of 4-thio-6-azauridine-5 -phosphate which was obtained by phosphorylation of 2, 3 -isopropyl-iden-4 thio-6-azauridine with pyrophosphoryl chloride. From mor-pholidate of 6-azacytidine-5 -phosphate, 6-azacytidine-5 -diphosphate was prepared by the action of phosphoric acid. ... 

Using tandem MS (DFS with EI/FPFD source), electron impact and collision activation mass spectra of a THF extract of an orthopaedic polymer bandage identified IV-isopropyl-A/ -phcnyl-p-phenylenediamine (IPPD, m/z 226) as a cause for contact dermatitis [232]. Fl-MS of the extract of surgeons gloves indicated thio-bis (t-butylcresol) (m/z 358 343, after CID). 

The protonation of 185 and 186 with trifluoroacetic acid (TFA) gave 4-(/i t/-butylthio)-3,6-diphenyl- 193 and 4-(ter1-butylthio)-3,6-di(2-thienyl)thieno[3,4-f]thiophene-l(3//)-thione 194 (Scheme 18). The treatment of 193 with sodium hydride and then isopropyl iodide led to 4-(/i< t/-butylthio)-3,6-diphenyl-l-(isopropylthio)thieno[3,4-f]thio-phene 195 by the regeneration of the thieno[3,4-f]thiophene ring system, thus making possible the synthesis of other alkylthio-substituted thieno[3,4-(r]thiophene derivatives. When the reaction of 185 with TFA was carried out... 

The methyl, propyl, and benzyl 1-thio-a-D-glucofuranosides were prepared" by the original method (with neutralization by sodium hydroxide). Use of the method of Pacsu and Wilson" gave the methyl, ethyl, propyl, and isopropyl 1-thio-a-D-ribofuranosides in yields ranging from 65 to 80%. Sodium (methyl l-thio-a-D-glucofuranosid)uronate and the ethyl and propyl analogs were obtained 7 similarly from the sodium salt of the... 

Sakamoto et al. provided an example of absolute asymmetric synthesis involving hydrogen abstraction by thiocarbonyl sulfur (Scheme 6). [24] Achiral A -diphenylacetyl-iV-isopropylthiobenzamide 33 and Y-diphenylacetyl-A-isopropyl(p-chloro)thio-benzamide 33 crystallize in chiral space group P2 2 2. Photolysis of the chiral crystals in the solid state gave optically active azetidin-2-ones whereas achiral thioketones were obtained as main products. When 33a was irradiated in the solid state at -45°C followed by acetylation (at -78°C), 2-acetylthio-3,3-dimethyl-l-diphenylacetyl-2-phenylaziridine (34a 39% yield, 84% ee), 4-acetylthio-5,5-dimethyl-2-diphenylmetyl-4-phenyloxazoline (35a 10% yield, 50% ee), 3,3-diphenyl-1-isopropy 1-4-... 

Purkayastha and Cochrane [155] compared electron capture and electrolytic conductivity detectors in the gas chromatographic determination of Prometon, Atraton (2-ethylamino-4-isopropylamino-6-methoxy-l,3,5-triazine), Propazine, Atrazine (2-chloro-4-ethylamino-6-isopropyl-amino-l,3,5-triazine), Prometryne, Simazine (2-chloro-4,6-6/s-ethylamino-l,3,5-triazine) and Ametryne (2-ethylamino-4-isopropylamino-6-methyl-thio-1,3,5-triazine) in inland water samples. They found that the electrolytic conductivity... 

HEK-293 hGH High-Five hsp70 HSV IPTG IRES kb Lac LCR LoxP LUC MCS human embryonic kidney cells human growth hormone TM BTI-TN-5B1-4 (cell line derived from the insect Trichoplusia ni) heat shock protein 70 herpes simplex virus isopropyl 1 -thio-fi-D-galactopyranoside internal ribosomal entry site kilobases lactose operon/repressor locus control region locus of crossover of PI luciferase isolated from firefly multiple cloning site... 

SYNS 4,6-BISaSOPROPYLAMINO)-2-METHYL-MERCAPTO-s-TRIAZINE 2,4-BIS(ISOPROPYLAMINO)-6-METHYLTHIO-s-TRIAZINE 2,4-BIS(ISOPROPYL-AMINO)-6-METHYLTHIO-l,3,5-TRIAZINE N,N -BIS(1-METHYLETHYL)-6-METHYL-THIO-l,3,5-TRIAZINE-2,4-DIAMINE CAPAROL G 34161 GESAGARD MERKAZIN 2-METHYLMERCAPTO-4,6-BIS(ISOPROP-YLAMINO)-s-TRIAZINE 2-iMETHYLTHIO-4,6-BIS(ISOPROPYLAMINO)-s-TRIAZINE POLISIN PRIMATOL Q PROMETREX PROMETRIN ... 

Other approaches have been used to apply the additivity concept and ascertain the binding energy contributions of various substituent (R) groups. Fersht et al. have measured the binding energies of various alkyl groups to aminoacyl-tRNA synthetases (64). Thus the AG values for methyl, ethyl, isopropyl, and thio substituents were determined to be 3.2, 6.5, 9.6, and 5.4 kcal/mol, respectively. 

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