Isopropyl N-phenylcarbamate

Potential Uses of These Polymers. We have studied the phenyl isocyanate modification of poly(vinyl alcohol) as a model system. Many uses exist for carbamates as medicines, pesticides and herbicides (67,68). For example, ethyl carbamate has been used to treat leukemia and multiple myeloma. Ethyl carbamate has also been used as an antidote for central nervous system poisoning by strychnine. The tranquilizer Meprobamate is a carbamate derivitive. Numerous pesticides and herbicides, such as Sevin and Propham, are also carbamate derivatives. Propham is isopropyl N-phenylcarbamate which bears a strong resemblence to the polymers of Equation 21, and this compound is used as a preemergence herbicide. Numerous other close analogs could be cited also. We might note also that the N-phenyl carbamoyl unit bears... 

Figure 3. Correlation of pl50 and partition data for some substituted phenyldimethyl-ureas and isopropyl N-phenylcarbamates [adapted from Hansch and Deutsch (12)]...

Templeman and Sexton (1945,1946) found that N-phenylcarbamates are toxic to monocotyledons but not dicotyledons. Of this group the first herbicide used in agriculture was isopropyl N-phenylcarbamate (IPC, propham, 3). 

Synonyms Carbanilic acid isopropyl ester IPC Isopropyl carbanilate Isopropyl carbanilic acid ester Isopropyl phenylcarbamate Isopropyl-N-phenylcarbamate o-lsopropyl-N-phenyl carbamate N-Phenyl isopropyl carbamate... 

Synonym Agermin, Ban-Hoe, Beet-Kleen, Birgin, Chem-Hoe, Collavin, IFC, IFK, INPC, IPC Chemical Name carbanilate acid isopropyl ester isopropyl carbanilate isopropyl-N-phenyl carbamate 1-methylethyl phenylcarbamate... 

ISOPROPYL PHENYLCARBAMATE see CBMOOO ISOPROPYI.-N-PHENYLCARB. MATE see CBMOOO o-ISOPROPYL-N-PHENYI. CARBAMATE see CBMOOO 2-ISOPROPYLPHENYL N-METHYLCARBAMATE see MIA250... 

Leroux and Gredt (46) described the enhanced sensitivity of benzimidazole-resistant biotypes of Penicillium expansum and Botrytis cinerea to several N-phenylcarbamate herbicides. Following this lead, methyl 3,5-dichlorophenylcarbamate and isopropyl... 

To elucidate relationships between structure and action, Moreland and Hill (1959) investigated on isolated chloroplasts the photolytic activity of a series of alkyl N-phenylcarbamates. The following order of activity was established jcc-butyl > n-butyl > -propyl > isopropyl > n-amyl ester. On substituting the imino hydrogen for an ethyl, phenyl or benzyl radical, the inhibiting effect decreased. Similarly, on replacing carbamyl oxygen with sulfur, activity considerably decreased. 

A similar compound is acylate, isopropyl N-acetoxy-N-phenylcarbamate (10). which was developed in the USSR (Melnikov, 1971). 

Propham. Phenylcarbamic acid l-methyiethyl ester carbanilic acid isopropyl ester N-phenyl isopropyl carbamate isopropyl carbaniiate O-isopropyl Al-phenyl carbamate INPC IPC IsoPPC. CwH,NO. mol wt 179.21. C 67.02%. H 7.31%. N 7.82%. O 17.86%. Prepn Allen. U.S. pat. 2,615,916 (1952 to Columbia-Southern Chem. Corp) Kovalenko, Zh. Obshch. Khim. 24, 1041 (1954) I. L. Her-manson, R. Olson, Trans. Kansas Acad, Set. 64, 231 (1961). Acute toxicity T. B. Gaines. R. E. Linder, Fundam. Appl Toxicol 7, 299 (1986). 

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