ISIS/Base 450 Subject

As annotated databases, WOMBAT and WOMBAT-PK continue to evolve in time - not only with the addition of more entries but also with updates and restructuring of the biological, clinical, and chemical information, which is subject to revision even after the data are captured and indexed. The inclusion of the precomputed properties panel allows the users to quickly identify rule-of-five or rule-of-three compliant datasets, or to constrain the query with respect to, for example, flexible bonds, PSA, computed solubility or LogP, and so on. WOMBAT and WOMBAT-PK are currently available in the MDL Isis/Base format. WOMBAT is also integrated in CABINET (Chemical And Biological... 

The Institute of Scientific Information (ISI, Philadelphia, Pennsylvania) operates a computer-based weekly service called ASCA (Automatic Subject Citation Alert). Articles from prime scientific journals may be located through cited item terms as well as through title terms. Clusters of articles with common references will usually be about the same subject, so a reference used as a profile term will locate articles citing that reference, as articles are published. A similar principle is employed in the Science Citation Index for retrospective searching, where all items having a common reference are brought together beneath the item they cite. 

In-service inspection and monitoring is based on the requirements of ASME section XI, Div 3. For the main vessel, in addition to ASME requirements of continuous monitoring, ultrasonic examination is planned to be carried out through the main vessel - safety vessel interspace (300 mm nominal gap). A periscope is provided for visual examination of reactor internals. Eddy current inspection is under development for the SG tubes. SG tube size and expansion bend design takes into account this inspection requirement. Ultrasonic examination is planned for the dissimilar joints of the roof slab - main vessel and SG transition joint. The subject of ISI for other reactor components important to safety is under study. For the safety related reactor assembly components, which are non-inspectable, an additional factor of safety in design is envisaged. 

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