Ischemic neuronal death

Glutamate-mediated excitotoxicity contributes to ischemic neuronal death 288... 

Choi, D. W. and Rothman, S. M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Anna. Rev. Neurosci. 13 171-182,1990. 

Chizh BA, Headley PM, Tzschentke TM (2001) NMDA receptor antagonists as analgesics focus on the NR2B subtype. Trends Pharmacol Sci 22 636-642 Choi DW (1995) Calcium stiU center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 18 58-60... 

Choi DW (1995) Calcium still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 18 58-60. 

Pellegrini-Giampietro, D. E. (2003). The distinct role of mGlul receptors in post-ischemic neuronal death. Trends Pharmacol. Sci. 24, 461—470. 

Chum S. B., Taft W. C., Billingsley M. S., Blair R. E., and DeLorenzo R. J. (1990) Temperature modulation of ischemic neuronal death and inhibition of calcium/ calmodulin-dependent protein kinase II in gerbils. Stroke 21,1715-1721. 

Mild hypothermia has gained attention in recent years after laboratory studies showed a significant reduction in ischemic neuronal death... 

Rami, A., 2003. Ischemic neuronal death in the rat hippocampus the calpain-calpastatin-caspase hypothesis, Neurobiol. Dis., 13, pp. 75-88. 

Carpenedo R, Meli E, Peruginelli F, Pellegrini-Giampietro DE, Moroni F (2002) Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures. J Neurochem 82 1465-1471... 

PCP binds with high affinity to sites located in the cortex and limbic structures, resulting in blocking of iV-methyl-D-aspartate (NMDA)-type glutamate receptors see Chapter 12). LSD and other psychedelics do not bind to NMDA receptors. There is evidence that NMDA receptors are involved in ischemic neuronal death caused by high levels of excitatory amino acids as a result, there is interest in PCP analogs that block NMDA receptors but with fewer psychoactive effects. 

Yamashima T. Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol. 2000 62 273-295... 

PARP l Inhibitors and Post-Ischemic Neuronal Death... 

Pellt rini-Giampietro DE, Pen t metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death Time-course and mechanisms. Neuropharmacology 1999 38 1607-1619. 

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