Spatial Memory Deficit and the Apoptotic Neuronal Death in Ischemic Rats

Improvement of the Spatial Memory Deficit and the Apoptotic Neuronal Death in Ischemic Rats 

In the course of trials to evaluate the efficacy of L-PDMP on memory in vivo, we have tested the effect of the two PDMP isomers on the deficit of previously acquired special memory after transient forebrain ischemia in rats (Inokuchi et al., 

After behavioral evaluation in the 8-arm radial maze task, the rat s brain was fixed and apoptosis was identified in the hippocampal CA1 by TUNEL assay. Apoptotic cells were found in vehicle-treated rats on the 7th day after ischemia (mean F S.E.M. 78.4 F 5.7 TUNEL-positive cells/mm2). As shown in Fig. 8, 

we confirmed the amelioration by L-PDMP of the ischemia-induced deficit of spatial cognition and apoptotic cell death in GA1 even when treatment was started 24 h after repeated cerebral ischemia. 

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