Glutamate receptors types

Joly, C., Gomeza, J., Brabet, I., Curry, K., Bockaert, J., and Pin, J.-P. (1995) Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants comparison with mGluRl../. Neurosci. 15, 3970-3981. 

Ciruela, F., Giacometti, A., and Mcllhinney, R. A. (1999) Functional regulation of metabotropic glutamate receptor type lc a role for phosphorylation in the desensitization of the receptor. FEBS Lett. 462,278-282. 

Perroy, J., Prezeau, L. M. D. W., Shigemoto, R Bockaert, J., and Fagni, L. (2000) Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. J. Neurosci. 20,7896-7904. 

Enz, R. and Croci, C. (2003) Different binding motifs in the metabotropic glutamate receptor type 7b for filamin-A, PP1C, PICK1 and syntenin allow the formation of multimeric protein complexes. Biochem. J. 372,183-191. 

Ciruela, F., Soloviev, M. M., Chan, W. Y and Mcllhenney, R. A. (2000) Homcr- Ic/Vcsl-1L modulates the cell surface targeting of group I metabotropic glutamate receptor type la evidence for an anchoring function. Mol. Cell. Neurosci. 15, 36-50. 

Nakamura M., Sato K., Fukaya M., Araishi K., Aiba A., Kano M., and Watanabe M. (2004). Signaling complex formation of phospholipase C/54 with metabotropic glutamate receptor type la and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur. J. Neurosci. 20 2929-2944. 

Miyata M., Kashiwadani H., Fukaya M., Hayashi T., Wu D. Q., Suzuki T., Watanabe M., and Kawakami Y. (2003). Role of thalamic phospholipase C/S4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain. J. Neurosci. 23 8098-8108. 

Vanhoose AM, Winder DG. 2003. NMDA and betal-adrenergic receptors differentially signal phosphorylation of glutamate receptor type 1 in area CA1 of hippocampus. J Neurosci 23 5827-5834. 

The CaR is expressed in many cells such as parathyroid cells and C cells in the thyroid gland. It is also expressed in the kidneys, osteoblasts, in the gastrointestinal mucosa, and hematopoietic cells in bone marrow. It has been found that CaR is expressed in different amounts on the cell face of many cell types and in diverse species. CaR is a member of the G protein-coupled receptor family with seven hydrophobic transmembrane helices in the plasma membrane. It has a large N-terminal domain with about 600 amino acids located in the extracellular environment and is essential for sensing extracellular calcium concentration. CaR has a large cytosolic C-terminal domain with about 200 amino acids that is subjected to phosphorylation. A dimeric structure has been proposed based on the known crystal structure of the metabotropic glutamate receptor type 1. 

Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R (2004b) Block of long-teim potentiation by naturally secreted and syntlietic amyloid beta-peptide in hippocampal slices is mediated via activation of tlie kinases c-Jun N-tenninal kuiase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kuiase as well as metaboti opic glutamate receptor type 5. J Neurosci 24 3370-3378. 

Chavis P, Shinozaki H, Bockaert J, Fagni L (1994) The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J Neuwsci... 

Makoff A, Lelchuk R, Oxer M, Harrington K, Emson P (1996a) Molecular characterization and localization of human metabotropic glutamate receptor type 4. Mol Brain Res 57 239-248. 

Yatsushiro S, Yamada H, Hayashi M, Tsuboi S, Moriyama Y (1999) Functional expression of metabotropic glutamate receptor type 5 in rat pinealocytes. NeuroReport 70 1599-1603. 

Mela F, Marti M, Dekundy A et al (2007) Antagonism of metabotropic glutamate receptor type 5 attenuates 1-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson s disease. J Neurochem 101 483 497... 

Varney MA, Cosford ND, Jachec C et al (1999) SIB-1757 and SIB-1893 selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J Pharmacol Exp Ther 290 170-181... 

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