Ischemic heart disease syndrome

About 4.5 million Americans have heart failure (HF). It is the most frequent cause of hospitalization for individuals older than 65 years. Some patients, with treatment, may lead nearly normal lives, whereas more than 50% of individuals with severe HF die each year. HF is a complex clinical syndrome that can result from any number of cardiac or metabolic disorders such as ischemic heart disease, hypertension, or hyperthyroidism. Any condition that impairs the ability of the ventricle to pump blood can lead to HF In HF, die heart... 

In general, treatment of the asthma underlying NSAlDs sensitivity should follow standard asthma guidelines. This type of asthma is often severe and frequently high doses of inhaled corticosteroids and daily doses of oral corticosteroids are necessary. A special treatment option is a chronic desensitization to aspirin [8]. Desensitization and aspirin maintenance is routinely used in some centers for treatment of chronic rhinusinusitis with nasal polyposis. It is the only available procedure which allows AIA patients with ischemic heart disease to use aspirin. During the state of desensitization to aspirin, not only aspirin but almost all strong NSAIDs are tolerated, so desensitization and NSAID maintenance could be used for treatment of rheumatic disease or chronic pain syndromes. 

O Ischemic heart disease results from an imbalance between myocardial oxygen demand and oxygen supply that is most often due to coronary atherosclerosis. Common clinical manifestations of ischemic heart disease include chronic stable angina and the acute coronary syndromes of unstable angina, non-ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction. 

The major goals for the treatment of ischemic heart disease are to prevent acute coronary syndromes and death, alleviate acute symptoms of myocardial ischemia, prevent recurrent symptoms of myocardial ischemia, and avoid or minimize adverse treatment effects. 

V16. Vijtek, L., Jirsa, M., Brodanova, M., Kalab, M., Marecvek, Z., Danzig, V., Novotny, L., and Kotal, P., Gilbert syndrome and ischemic heart disease A protective effect of elevated bilirubin levels. Atherosclerosis 160, 449-456 (2002). 

The term acute coronary syndrome (ACS) encompasses most of the patients defined so far in this chapter who present with unstable ischemic heart disease. Most of these syndromes occur in response to an acute event in the coronary artery when circulation to a region of the heart is obstructed. If the obstruction is high grade and persists, then necrosis usually ensues. Since necrosis takes some time to develop, it is apparent that therapy, including opening the blocked coronary artery in a timely fashion, often can prevent some of the death of myocardial tissue. These syndromes are usually, but not always, associated with chest discomfort. 

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