Irritable bowel syndrome probiotics

Madden JA, Hunter JO A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics. Br J Nutr 2002 88(suppl 1) S67-S72. 

Hamilton-Miller JMT Probiotics in the management of irritable bowel syndrome A review of clinical trials. Microb Ecol Health Dis 2001,13 211-215. 

Clinical trial Multispecies probiotic supllementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota. Aliment. Pharmacol. Ther. 27(1), 48-57. 

Brigidi, R, Vitali, B., Swennen, E., Bazzocchi, G., and Matteuzzi, D. Effects of probiotic administration upon the composition and enzyme activity of human faecal microbiota in patients with irritable bowel syndrome. Res. Microbiol, 152, 735, 2001. 

Kim, H.J., Camilleri, M., McKinzie, S., Lempke, M.B., Burton, D.D., Thomforde, G.M., and Zinsmeister, A.R. A randomized controlled trial of a probiotic VSL 3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol. Ther., 17, 895, 2003. 

Saggioro, A. Probiotics in the treatment of irritable bowel syndrome, /. Clin. Gastroenterol, 38, S104, 2004. 

The probiotic strain E. faecium PR88 was studied in clinical trial (Allen et al. 1996). The consumption of this strain led to alleviation of the symptoms of irritable bowel syndrome in humans. The efficacy and safety of live combmedBifidobacterium, Lactobacillus and Enterococcus capsules in treatment of irritable bowel syndrome was also demonstrated (Fan et al. 2006). E. faecium functions as a probiotic strain inhibiting biofilm formation by Streptococcus mutants, which is an etiological agent for dental caries (Kumada et al. 2008). 

AUen WD, Lingood MA, Porter P. (1996) Enterococcus organisms and their use as probiotics in alleviating irritable bowel syndrome symptoms. European Patent 0508701 (Bl)... 

Clarke, G., Cryan, J. R, Dinan, T. G., Quigley, E. M. (2012). Review article probiotics for the treatment of irritable bowel syndrome-focus on lactic acid bacteria. Alimentary Pharmacology and Therapeutics, 35,403-413. 

McFarland, L.V., and Dublin, S. 2008. Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World J Gastroentero 14(17), 2650-2661. 

Shavakhi, A., Minakari, M., Farzamnia, S., et al. (2014) The effects of multi-strain probiotic compound on symptoms and quality-of-life in patients with irritable bowel syndrome A randomized placebo-controlled trial. Adv Biomed Res 3, 140. 

The development of the intestinal microbiota needs to be characterized to define the composition that helps us to remain healthy. Specific aberrations in the intestinal microflora may predispose to disease. Such aberrations have been identified in allergic disease, including decreased numbers of bifidobacteria and an atypical composition of bifidobacterial microflora. Also, aberrations in Clostridium content and composition have been reported to be important. Similar predisposing factors may also exist in the case of microflora and both inflammatory gut diseases and rotavirus diarrhea. Microflora aberrations have also been reported in rheumatoid arthritis, juvenile chronic arthritis, ankylosing spondylitis, and irritable bowel syndrome patients. A thorough knowledge of the intestinal microflora composition will offer a basis for future probiotic development and the search for new strains for human use. Many diseases and their prevention can be linked to the microflora in the gut. 

Irritable bowel syndrome There is a rationale for investigating the effect of probiotics in the treatment of this common disorder where intestinal motility and dysfunctions in the intestinal microflora are important factors to consider. In a recent study using L. plantarum 299v, a reduction of symptoms was reported. Enterococcus faecium preparations have also been evaluated for the treatment of patients with irritable bowel syndrome, and although patient-recorded symptoms did not show significant differences, the physician s subjective clinical evaluation revealed an improvement. 

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