Irritable bowel syndrome antispasmodics

Buscopan contains hyoscine butylbromide, which is a quaternary ammonium compound with antimuscarinic properties. It is used as an antispasmodic and therefore may be useful in irritable bowel syndrome. Hyoscine butylbromide, as with all antimuscarinics, must be used with caution in patients with prostatic hypertrophy, as they may lead to urinary retention. 

Colofac is the proprietary preparation of mebeverine, which is an antispasmodic useful in irritable bowel syndrome. Mebeverine is a direct relaxant of the smooth muscle and, unlike hyoscine, is not an antimuscarinic. 

Mebeverine is an antispasmodic that reduces gastric and intestinal motility by direct relaxation of the intestinal smooth muscle. It can be used to relieve pain in irritable bowel syndrome and diverticular disease. Like all antispasmodics, mebeverine is contraindicated in paralytic ileus. 

In the treatment of irritable bowel syndrome, often a therapeutic dilemma, there is some evidence that a high fibre maintenance diet combined with short-term antispasmodics may be beneficial. 

Nonselective antimuscarinic drugs have been employed in the therapy of peptic ulcers (see Chapter 40) because they can reduce gastric acid secretion they also have been used as adjunctive therapy in the treatment of irritable bowel syndrome. Antimuscarinic drugs can decrease the pain associated with postprandial spasm of intestinal smooth muscle by blocking contractile responses to ACh. Some of the agents used for this disorder have only antimuscarinic activity (e.g., propantheline), while other drugs have additional properties that contribute to their antispasmodic action. Dicyclomine (Bentyl) and oxybutynin (Ditropan) at therapeutic concentrations primarily have a direct smooth muscle relaxant effect with little antimuscarinic action. 

C. Ginkgo would be the most likely herbal treatment to benefit this patient, since it would improve cerebrovascular blood flow and cognitive function. Vertigo and tinnitus may also respond, although there is more evidence for the former. GarUc is traditionally used for cardiovascular benefits (Upid, blood pressure reduction), but it would be unlikely to produce immediate results. Peppermint is used as an antispasmodic in irritable bowel syndrome, while ginger tea is a common carminative (gas reducer) and motion sickness treatment. Valerian is useful as a sedative. 

Cimetropium is a QTA representing an N-alkylated derivative of scopolamine (Fig. 1). It exhibits antispasmodic activity on smooth muscle cells in the GIT. Therefore, it is clinically used for oral long-term treatment of irritable bowel syndrome with minimal effects on vascular receptors [32, 61]. 

The oil of Mentha piperita (peppermint) contains cineol, limonene, menthofuran, menthol, and menthone. It has been used as a carminative and antispasmodic for esophageal spasm and irritable bowel syndrome (10). 

Mebeverine is an antispasmodic drug that is claimed to act directly on the colonic mnscle and is virtnally free of systemic adverse reactions. It has been nsed to treat irritable bowel syndrome, bnt its therapentic effect is poor. 

Alupenf" ordprenaUne. alverine [inn] (alverine citrate [usan]) is a diphenyldipropylamine compound, a MUSCARINIC CHOLINOCEPTOR ANTAGONIST, which can be used as an ANTISPASMODIC AGENT to treat irritable bowel syndrome, alverine citrate alverine. amacid brilliant blue indigotin disulfonate sodium. 

CHOLINOCEPTOR ANTAGONIST and CALCIUM-CHANNEL BLOCKER activity. It can be used as an antispasmodic in the treatment of irritable bowel syndrome, pinazepam [INN] (Z905) isoneofthe. ... 

Atropine is a GI anticholinergic combination. This combination promotes peripheral antichohnergic/antispasmodic action (decreases GI motility) and provides mild sedation. It is possibly effective for treatment of irritable bowel syndrome and acute enterocolitis. It also may be useful as adjunctive therapy for duodenal ulcer. 

Methscopolamine is a quaternary anticholinergic agent that competitively inhibits action of acetylcholine at muscarinic receptors. Methscopolamine, an anticholinergic agent with gastrointestinal antispasmodic properties (2.5 to 5 mg p.o. one-half hour before meals), is used as an adjunctive therapy in peptic ulcer and irritable bowel syndrome (IBS). 

The elderly client diagnosed with irritable bowel syndrome (IBS) is prescribed propantheline (Pro-Banthine), an antispasmodic. Which signs or symptoms indicate an adverse reaction to the medication ... 

A review of 16 trials was conducted by Grigoleit and Grigoleit in 2005. They concluded that there was reasonable evidence that the administration of enteric-coated peppermint oil (180 200 mg) thrice daily was an effective treatment for irritable bowel syndrome when compared to placebo or the antispasmodic drugs investigated (mebeverine, hyoscyamine, and alverine citrate). 

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