Ipodic acid

Some of these triiodinated compounds are orally active, i.e. they are absorbed from the gastrointestinal tract after oral administration and imaging of the biliary system is possible following this route of administration. Examples are iopanoic acid, iophenoxic acid and sodium ipodate. A prerequisite for oral absorption is a balance of relatively hydrophilic and lipophilic moieties in the molecule. Numerous investigations have been performed to establish structure-activity relationships for this class of compounds, e.g. by Archer and Hoppe [70, 71]. Sodium salts are better absorbed than the free acids [72]. 

III.b.1.4. lodinated contrast media. When iodides or thioamides are contraindicated, the contrast media ipodate and iopanoic acid may be used to treat hyperthyroidism. These drugs rapidly inhibit conversion of T4 to T3 in the liver, kidney, brain and pituitary gland, and the effects are so rapid that they are sometimes helpful in the treatment of thyroid storm (see below). The drugs are non toxic and have prolonged effect. Precautions are similar to iodide,... 

The iodinated contrast agents, ipodate and iopanic acid are used in the treatment of hyperthyroidism. These drugs rapidly inhibit the conversion of T to T in the liver, kidney, brain and pituitary gland. 

Inhibition of 5 -deiodinase with decreased T3, increased rT3 Iopanoic acid, ipodate, amiodarone, blockers, corticosteroids, propylthiouracil, flavonoids... 

Ipodate, introduced in 1961, can yield visualization of both gall bladder and bile ducts. Tyropanoate, iopanoic acid, and ipodate are widely used in oral cholecystography. They show about the same efficacy but differ in the intensity of opacification,the frequency of dim and absent shadows, and the frequency of side effects. Russell and Frederick (867) compared these three agents but failed to demonstrate the superiority of any one of them. locetamic acid was favorably compared with and preferred to the above three agents, but skin reactions were reported in a few cases (775,868, 869). 

Other drugs that are useful in the rapid treatment of the severely thyrotoxic patient are agents that inhibit the peripheral conversion of thyroxine to triiodothyronine. Dexamethasone (0.5 to 1 mg two to four times daily), and the iodinated radiological contrast agents iopanoic acid (Telepaque, 500 to 1000 mg once daily), and sodium ipodate (Qragrafin, 500 to 1000 mg once daily) are effective in preoperative preparation. Neither iopanoic acid nor sodium ipodate is available in the United States. Cholestyramine has been used in severely toxic patients to bind thyroid hormones in the gut and thus block the enterohepatic circulation of the iodothyronines. 

Orai choiecystogram dyes (sodium ipodate, iopanoic acid) Amiodarone... 

Add flowcharts. We have delineated in a visual way (much like the algorithms students are familiar with on their iPods and iPhones ) a pathway to follow for various topics. Among these are stoichiometry, naming compounds, and determining the acidity or basicity of a salt. 

Russell, J. G. and Frederick, P. R. (1974) Clinical comparison of tyropanoate sodium, ipodate sodium and iopanoic acid. Radiology, 112, 519. 

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