Sodium ipodate

Some of these triiodinated compounds are orally active, i.e. they are absorbed from the gastrointestinal tract after oral administration and imaging of the biliary system is possible following this route of administration. Examples are iopanoic acid, iophenoxic acid and sodium ipodate. A prerequisite for oral absorption is a balance of relatively hydrophilic and lipophilic moieties in the molecule. Numerous investigations have been performed to establish structure-activity relationships for this class of compounds, e.g. by Archer and Hoppe [70, 71]. Sodium salts are better absorbed than the free acids [72]. 

The iodine-containing oral cholecystographic contrast agents (OCAs) include sodium ipodate Oragrafin),... 

Karpman BA, Rapoport B, Filetti S, Fisher DA. Treatment of neonatal hyperthyroidism due to Graves disease with sodium ipodate. J Clin Endocrinol Metab 1987 64(l) 119-23. 

When five patients with type 2 amiodarone-induced hyperthyroidism were treated with a combination of an oral cholecystographic agent (sodium ipodate or sodium iopanoate, which are rich in iodine and potent inhibitors of 5 -deiodinase) plus a thionamide (propylthiouracil or methimazole) after amiodarone withdrawal, all improved substantially within a few days and became euthyroid or... 

Cyr, D.G. and J.G. Eales. The effects of sodium ipodate (ORAgrafin) on thyroid function in rainbow trout, Salmo gairdneri. Gen. Comp. Endocrinol. 63 86-92, 1986. 

Other drugs that are useful in the rapid treatment of the severely thyrotoxic patient are agents that inhibit the peripheral conversion of thyroxine to triiodothyronine. Dexamethasone (0.5 to 1 mg two to four times daily), and the iodinated radiological contrast agents iopanoic acid (Telepaque, 500 to 1000 mg once daily), and sodium ipodate (Qragrafin, 500 to 1000 mg once daily) are effective in preoperative preparation. Neither iopanoic acid nor sodium ipodate is available in the United States. Cholestyramine has been used in severely toxic patients to bind thyroid hormones in the gut and thus block the enterohepatic circulation of the iodothyronines. 

Sodium salt, CjjH.jIjNjNaOj, sodium ipodate, Biloptin, Oragrafin-Sodium. Bitter leaflets from water + acetone, mp 303-304 (decompn with evolution of iodine), Very freely sol in water freely sol in methanol, ethanol. Practically insol in acetone, ether. Soly in DMF and DMSO about 33 g /100 ml in dimethyl acetamide about 66 g/100 ml. LDm in mice (mg/kg) 290 i.v. 2570 orally (Hoppe). 

Orai choiecystogram dyes (sodium ipodate, iopanoic acid) Amiodarone... 

Russell, J. G. and Frederick, P. R. (1974) Clinical comparison of tyropanoate sodium, ipodate sodium and iopanoic acid. Radiology, 112, 519. 

Ipodate, which inhibits the conversion of thyroxine to triiodothyronine, is useful in reducing the intensity of thyroid storm. Sympathoplegic drugs are also useful, and propranolol is the most commonly used agent. Further release of hormone from the gland is blocked by intravenous administration of sodium iodide supplemented by oral potassium iodide. Synthesis is inhibited by oral or, if necessary, parenteral antithyroid drugs. Corticosteroids are sometimes used. 

Ipodate calcium Ipodate sodium Iso-octane Isopregenone Isopropamide iodide Isosorbide dinitrate Isuprel ethanesulfonate... 

---