Iophenoxic acid

Some of these triiodinated compounds are orally active, i.e. they are absorbed from the gastrointestinal tract after oral administration and imaging of the biliary system is possible following this route of administration. Examples are iopanoic acid, iophenoxic acid and sodium ipodate. A prerequisite for oral absorption is a balance of relatively hydrophilic and lipophilic moieties in the molecule. Numerous investigations have been performed to establish structure-activity relationships for this class of compounds, e.g. by Archer and Hoppe [70, 71]. Sodium salts are better absorbed than the free acids [72]. 

Chemical Name a-Ethyl-3-hydroxy-2,4,6-triiodobenzenepropanoic acid Common Name Iophenoxic acid Teridax Structural Formula ... 

Acidum iophenoicum Iophenoxic acid) se x ray contrast medium... 

Shapiro R. The effect of maternal ingestion of iophenoxic acid with serum protein bound iodine of the progeny. N Engl J Med 1961 264 378. 

Jankowski JJ, Feingold M, Gellis SS. Effect of maternal ingestion of iophenoxic acid (Teridax) on protein-bound iodine report of a family. J Pediatr 1967 70(3) 436-8. 

A number of substituted 2,4,6-triiodoben-zoic acid derivatives were introduced as chole-cystographic agents. Among them, bunamio-dyl and iophenoxic acid were later withdrawn by the manufacturers because bunamiodyl caused renal shutdown and iophenoxic acid caused high protein-bound iodine values persisting over many years. 

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