Ionizing radiation chronic

Radiation causes dominant lethal mutations in the medaka (Oryzias latipes) (Shima and Shimada 1991). Mosquitofish (Gambusia spp.) from radionuclide-contaminated ponds in South Carolina differed from conspecifics in reference ponds, as judged by the frequency of DNA markers, and this is consistent with the hypothesis that these DNA markers may originate from genetic elements that provide a selective advantage in contaminated habitats (Theodorakis et al. 1998). Ionizing radiation at low-level chronic exposure reportedly has no deleterious genetic effects on aquatic populations because exposure is compensated by density-dependent responses in fecundity (IAEA 1976). However, this needs verification. 

Dose In the context of chemicals, the temi dose means the amount, quantity, or portion of the chemical exposed to or applied to the target (e.g., a human being). It may also refer to a consistent measure used in toxicological testing to determine acute and chronic toxicities. An alternate definition is die amount of ionizing radiation energy absorbed per unit mass of irradiated material at a specific location, such as a part of die human body, measured in REMS, or an inanimate body, measured in rads. 

Three-dimensional dose-rate/time/response surfaces for chronic exposure to carcinogens and ionizing radiation clarify the interactive roles of competing risks (Raabe, 1987). The three dimensions are average dose rate, exposure time, and risk. The unproved conceptualization afforded by them contributes to the planning and evaluation of epidemiological analyses and experimental studies involving chronic exposure to radiation toxicants (Raabe, 1987). 

Fliedner, T.M., Graessle, D.H. (2008). Hematopoietic cell renewal systems mechanisms of coping and failing after chronic exposure to ionizing radiation. Radiat. Environ. Biophys. 47 63-9. 

M. Nonchemical physical exposures in the workplace are important because they can cause systemic effects that mimic chemical toxidromes. The most important example is heat stress, which is a major occupational health issue. Other relevant nonchemioal, work-related physical exposure types include ionizing radiation, nonionizing radiation (such as ultraviolet, infrared, and microwave exposure), and increased barometric pressure (eg, among caisson workers). Except for extremes of exposure, the adverse effects of these physical factors are generally associated with chronic conditions. 

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