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Ionic gelation method

Figure 19.36 Experimental setup for the preparation of nano chitosan by ionic gelation method. Figure 19.36 Experimental setup for the preparation of nano chitosan by ionic gelation method.
The ionic gelation method has received tremendous attention in recent years for the preparation of nanocarriers for low molecular dmgs [148]. As far as chitosan-based nanoparticles are concerned, sodium tripolyphosphate (TPP) is usually used as ionic crosslinking agent. Chitosan-based nanoparticles can also be prepared using self-assembly methods. In this case, polyanionic compounds are selected and then allowed to react separately with chitosan and modified chitosan. Electrostatic... [Pg.107]

M.R. Avadi, A.M.M. Sadeghi, N. Mohammadpour, S. Abedin, F. Atyabi, R. Dinarvand, and M. Rafiee-Tehrani, Preparation and characterization of insuhn nanoparticles using chito-san and Arabic gum with ionic gelation method. Nanomedicine Nanotechnology, Biology and Medicine, 6 (1), 58-63,2010. [Pg.364]

Methods Based on Ionic Interactions 36.3.4.1 Ionic Gelation... [Pg.750]

A technique used to obtain spherical particles is the spray-drying technique. The spray-drying method has reportedly provided small-size, protein-loaded chitosan-alginate microparticles with appropriate protein immobilization capacity [98]. It has been applied to BSA/sodium alginate/chitosan solutions to obtain microparticles [98]. Moreover, chitosan nanoparticles can be obtained by ionic crosslinking method. It has produced nanoparticles based on ionic gelation process of tripolyphosphate (TPP) and chitosan [99]. Nevertheless, another physical method called layer-by-layer can be used to form chitosan particles. Through the layer-by-layer technique submicron (40 nm) capsules with poly(L-aspartic acid) and chitosan for transmucosal delivery of proteins and peptides have been obtained [100]. [Pg.447]

Shanmuganathan et al. improved this method [18]. Chitosan microspheres (CSM) were prepared by the W/0 emulsification process along with an ionic coacervation technique. The KOH solution in / -octanol was added into the w/o emulsion of chitosan drop by drop. Then the ionic gelation was initiated. After the reaction, the chitosan microspheres were removed and rinsed in demineralized water baths. The whole process was carried out at room temperature. [Pg.1347]


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