Polyvinyl pyrrolidone-iodine solution

Iodophors are complexes of iodine with a surface-active agent such as polyvinyl pyrrolidone (PVP povidone-iodine). Iodophors retain the activity of iodine. They kill vegetative bacteria, mycobacteria, fungi, and lipid-containing viruses. They may be sporicidal upon prolonged exposure. Iodophors can be used as antiseptics or disinfectants, the latter containing more iodine. The amount of free iodine is low, but it is released as the solution is diluted. An iodophor solution must be diluted according to the manufacturer s directions to obtain full activity. 

Polyvinyl Pyrrolidone-Iodine Gargle Solution Concentrate... 

Dissolve polyvinyl pyrrolidone-iodine powder and sodium saccharin in 440 g water to obtain a clear solution. 

Dissolve polyvinyl pyrrolidone-iodine and saccharin in water and mix with solution of items 4 to 7. 

Slowly add polyvinyl pyrrolidone-iodine to the well-stirred solution. This creates a brown, transparent liquid having a pH of 4.5. 

Add Texapon and slowly dissolve the polyvinyl pyrrolidone-iodine. This creates a brown, clear solution having a certain viscosity and a pH of 3 to 4. 

Dissolve the polyvinyl pyrrolidone-iodine (and Lutrol F 127) in the mixture of the buffer solutions (and Lutrol E 400). 

Dissolve polyvinyl pyrrolidone-iodine in about 600 mL citric acid-phosphate buffer (pH 5.0) solution (made above) in a suitable stainless steel mixing tank. 

Povidone-iodine (PVP-I, polyvinyl pyrrolidon-iodine complex, Betadine, Betaisodona, Braunol, Braunosan H, Disadine D.P., Disphex, Efo-Dine, Inadine, Isodine, Proviodine, Traumasept, Videne, CAS no. 25655-41-8). This is the most widely used iodophor and does not have the irritant properties associated with iodine solutions. At a strength of 7.5% in a surfactant base, povidone-iodine is applied as a surgical scrub, and at 4% is used as a shampoo or skin cleanser. Because of the small amounts of free iodine (less then 1 ppm in a 10% solution), antimicrobial effects are moderate in comparison with iodine solutions. 

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