Inverse temperature transitions hydrophobic consilient

T, to a new value of T, caused by an energy input represented by % to provide a measure of the change in Gibbs free energy for hydrophobic association of the protein-based polymer. Therefore, Tt, the onset temperature for the inverse temperature transition, represents an intrinsic property of the hydrophobic consilient mechanism of energy conversion. 

Our focus now turns to the physical basis whereby the energy conversions of the hydrophobic consilient mechanism occur, and, of course, it becomes an issue of what controls the inverse temperature transition of hydrophobic association. 

Hydrophobic association on raising the temperature is the most fundamental aspect of the consilient mechanism, arising as it does from the inverse temperature transition. An equivalent statement would be that hydrophobic dissociation on lowering the temperature is fundamental to the consilient mechanism. Historically, this has been called cold denaturation of enzymes. In our view, those protein systems that associate on heating to physiological temperatures in order to achieve a functional state should be considered in terms of the consilient mechanism. 

Yet much more phenomenological data, showing the coherence of phenomena between hemoglobin function and the consilient mechanism of the inverse temperature transition for hydrophobic association, continues below, before direct examination of the molecular structures, as generally presented. Subsequently, in section 7.3, the molecular structures are examined to look for the specific interactions most significant to the consilient mechanism. 

In our view, the hydrophobic and elastic consilient mechanisms comprise the vital force of living matter. The forces arising out of inverse temperature transitions and elastic deformation, for example, apolar-polar repulsion and damping of backbone mobility on deformation, couple to create biology s vital force. ... 

E.2.8 The Hydrophobic Consilient Mechanism Derives from the Inverse Temperature Transition... 

Biology s reversal of the much-noted arrow of time and equivalently biological evolution derive simply from fundamental reality of biosynthesis within the context of inverse temperature transitions as expressed in the hydrophobic consilient mechanism. The production of a new and improved protein-based machine occurs by chance, but most significantly it occurs at a cost in energy no greater than that required to produce the initial less useful protein-based machine. This is the nature of the biosynthesis of protein and of the other great macromolecules (the nucleic acids, DNA and RNA) of biology. 

Thus, from the perspective of the inverse temperature transition, evolution and natural selection become apparent consequences for protein-based machines that function by the hydrophobic and elastic consilient mechanisms. 

---