Intravenous injections of drugs

Effect of dose of single intravenous injection of drug on plasma levels. 

Brockbank, W. The less ancient art of intravenous injection of drugs. In Ancient Therapeutic Arts The Fitzpatrick Lectures Delivered in 1950 and 1951 at the Royal College of Physicians, William Heinemann Medical Books, Ltd. London, 1954. 

Intravenous drug injection is associated with rapid drug effects, making it the preferred route of some drug abusers. Intravenous injection of drugs is considered dangerous because large quantities can reach the site(s) of action so quickly. 

Review the advantages and disadvantages of oral administration and intravenous injection of drugs. 

In this section the intraperitoneal route of liposome administration will be discussed. For a number of diseases this route of administration may be preferred over the intravenous route of administration of liposomes. For example, intraperitoneal injection of drug-... 

We consider the following synthetic plasma concentrations which are supposedly obtained after intravenous injection of 10 mg of a drug ... 

For efficacy experiments, HCT-116 xenograft tumors (8 in each group) received intravenous injections of either irinotecan 60 mg/kg (4 treatments, every 4 days) or edotecarin 30 mg/kg (2 treatments, every 7 days). Drug doses... 

Figure 5.9. The concentration-time course of (a) naproxen and (b) captopril in the kidney after intravenous injection of the parent drug or the drug-lysozyme (LZM) conjugate. Values are given as means + SEM.

An acute intravenous injection of clonidine may produce a transient pressor response that apparently is due to stimulation of peripheral vascular a-receptors. The pressor response does not occur after oral administration, because the drug s centrally mediated depressor action overrides it. 

Combined use of any of the drugs in this category increases the risk of death. While a single drug may not depress respiration markedly, a combination of drugs can do so. The antidote for benzodiazepine overdose is an intravenous injection of Romazi-con (flumazenil). 

In rat, dog, and calves (162, 163), flumequine is glucuronidated and, to a lesser extent, is hydroxylated to 7-hydroxy llurnequine (164). In sheep, flumequine is widely distributed in edible tissues after a single intravenous injection of 12 mg/kg bw, residues in kidney were higher than those in liver and muscle at 24 h after drug administration (165). 

I11 the therapy of deep venous thrombosis, heparin is commonly administered. This drug takes effect immediately to prevent further thrombus formation. However, heparin is regarded as a hazardous drug and possibly may be tlie leading cause of drug-related deaths 111 hospitalized patients who are relatively well. Usually administered intravenously, preferably by pump-dnven infusion at a constant rate rather than by intermittent injections, it sometimes may cause major bleeding, which is particularly hazardous if it is intracranial. The action of heparin can be terminated almost immediately by intravenous injection of protamine sulfate, but where there may be less urgency, vitamin Ki may be used. The vitamin preparation may be administered intravenously, intramuscularly, or subcutaneously. 

Diethylstilbestrol continues to be recommended in some centers as one of the agents of last resort when prostate cancer proves refractory to steroid hormones or androgen deprivation therapy has done all it can (1). In a Japanese study in which 16 patients were given a daily intravenous injection of diethylstilbestrol diphosphate 250 mg for 28 days, the short-term response was favorable and the drug was well tolerated (2). 

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