Intravenous glucose tolerance testing

Figure 10. Results of intravenous glucose tolerance test (IVGTT) using a normal dog in the case of glucose sensor I.

Fig. 6.19 Relation between glucose concentration, G, and time during an intravenous glucose tolerance test (IVGTT).

The mam indication for the intravenous glucose tolerance test is in clinical research to evaluate the first-phase insulin response to glucose (see Figure 25-13). The test is performed as described earlier, but samples are drawn as follows Two baseline samples 5 minutes apart (the latter immediately before infusion) and samples 1, 3, 5, and 10 minutes after the end of the glucose infusion. The first-phase insulin release is usually measured by the sum of the insuhn concentrations 1 and 3 minutes after the glucose bolus. Alternatively, the 0 to 10-minute incremental insulin area may be used. Like the OGTT, the intravenous glucose tolerance test has poor reproducibility. 

BinhTQ, Davis TME, Jchnston W, Thu LTA, Boston R, Danh PT, Anh TK Glucose metabolism in severe malaria minimal model analysis of the intravenous glucose tolerance test incorporating a stable glucose label. Metabolism (1997) 46,1435-40. 

CsogSr SI, Bomemisza P. The effect of clofibrate (Atromic on intravenous tolbutamide, oral and intravenous glucose tolerance tests. Clin Trials J (1977) 14,15-19. 

Fig. 2. Intravenous glucose tolerance test (IVGTT) on a sensor connected to a conscious freely-moving rat. (...) direct signal from glucose sensor using a glucose oxidase cellulose acetate membrane, (o) reference values using a Beckman glucometer.

Intravenous glucose tolerance test. This is used for investigating glucose metabolism when abnormal carbohydrate absorption is present. 

Vicini, P. and CobeUi, C. 2001. The iterative two-stage population approach to IVGTT minimal modeling improved precision with reduced sampUng. Intravenous glucose tolerance test Am. J. Physiol. Endocrinol. Metab. 280 E179-E186. 

Macaca nigra (Celebes black apes) (Fig. 1) have a species-specific diabetic syndrome (5) that is manifested in abnormal oral and intravenous glucose tolerance tests (IV-GTT), Impaired insulin response to an IV-GTT, less insulin in serum taken after an overnight fast, hyperglycemia, hypertriglyceridemia, hyperprebetalipo-proteinemia, and increased nonesterifled fatty acids. Cholesterol... 

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