Intraabdominal abscess treatment

Treatment regimens for intraabdominal infection can be judged as successful if the patient recovers from the infection without recurrent peritonitis or intraabdominal abscess and without the need for additional antimicrobials. A regimen can be considered unsuccessful if a significant adverse drug reaction occurs, reoperation or percutaneous drainage is necessary, or patient improvement is delayed beyond 1 or 2 weeks. 

The primary goals of treatment are correction of the intraabdominal disease processes or injuries that have caused infection and drainage of collections of purulent material (abscess). A secondary objective is to resolve the infection without major organ system complications (e.g., pulmonary, hepatic, cardiovascular, or renal failure) or adverse drug effects. Ideally, the patient should be discharged from the hospital with full function for self-care and routine daily activities. 

The goals of treatment are the correction of intraabdominal disease processes or injuries that have caused infection and the drainage of collections of purulent material (e.g., abscess). 

Intraperitoneal irrigation of antimicrobial agents for treatment of intraabdominal infection has been smdied often with conflicting results. Intraoperative antimicrobial irrigation does not improve patient outcomes in comparison with copious intraoperative irrigation with normal saline. Possibly the most important aspect of peritoneal irrigation is the dilutional effect on bacteria and adjuvants that promotes infection (intestinal contents and hemoglobin). Most system-ically administered antimicrobials easily cross the peritoneal membrane so that peritoneal fluid concentrations are similar to serum. " Confined areas, such as an abscess, can be expected to attain much lower antimicrobial concentrations. 

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