Interpretive strategies

McEvoy, J.G. In search of the chemical revolution interpretative strategies in the history of chemistry. Foundations of Chemistry 2 (2000) 47-73. 

Pellegrino R, Viegi G, Brusasco V et al. Series ATS/ERS task force standardisation of Lung function testing . Interpretative strategies for lung function tests. Eur RespirJ 2005 26 948-68. 

The same data-interpretation strategy is applied by Gangl et al. [13] in a study on the metabolism of the HIV-protease inhibitors ritonavir and indinavir (see Figure 10.2c). After the in vitro generation by incubation with human liver microsomes, the metabolites were extracted by means of LLE. Gradient elution LC-MS on an ion-trap instrument was applied to search for possible metabolites, which were subsequently fragmented in time-scheduled triple-quadrapole MS-MS. 

Strategies used for optimization of selectivity can basically be divided into three separate groups (a) the simultaneous strategy, (b) the sequential strategy, and (c) the interpretative strategy. 

This method enables prediction of the quahty of a separation on the basis of a relatively hmited number of the experimental data, collected in previous experiments. According to this approach, the chromatographic results are interpreted in terms of the retention functions, valid for each individual solute separately. Some good examples of the interpretative strategy are the so-called window diagrams approach [20] and the search for the extremum of the multiparameter response function with the aid of the genetical algorithm [21],... 

These models provided a quantitative relationship between physicochemical parameters and impedance response, but the application of interpretation strategies did not keep pace with the model development. Interpretation was based on graphical examination of plotted data. In simple cases, plots could be used directly as described in Chapter 18. For more complicated cases, simulations could be compared graphically to data to reveal qualitative agreement. 

Three approaches have been documented in the literature for incorporating the error structure of impedance data into interpretation strategies. One approach has been to assume a standard form for the stochastic errors. Two models are commonly used. Zoltowski and Boukamp advocated use of modulus weighting. Use of a modulus weighting strategy invokes an assumption that the standard deviation is proportional to the frequency-dependent modulus Z(o ) of the impedance, i.e.,... 

ERP radicalized Kuhn s philosophy of science with an infusion of interpretive strategies derived from phenomenology, hermeneutics and the philosophy of the later Wittgenstein. According to Collins, the job of the historian or soci-... 

American Thoracic Society. Lung function testing selection of reference values and interpretative strategies. Am Rev Respir Dis 1991 144 1202-1218. 

Schnell, E., Hammer, A. (1997). Integrating the FIRO-B with the MBTI Relationships, case examples, and interpretation strategies. Developing leaders. Palo Alto, CA Davies-Black. 

Intelligent computer assisted interpretation of spectroscopic data should be based on the knowledge from large structure oriented data collections. Both the inspection of spectral features and the statistical evaluation of similar structures (from library searches) can provide a set of probability ranked substructures which are readily assembled to target structures. The idea of substructure analysis allows the chemist to combine the results of different interpretation strategies, different databases and different spectroscopic methods to yield the structural information desired. Thus in a multidimensional data system hke SPECINFO structural noise can be effectively suppressed, if all information available in the spectroscopic laboratory is combined in a central intelligent computer system. 

Su et al. [24] studied the polymorphic transformation of n-mannitol by in situ Raman spectroscopy coupled with FBRM (focused beam reflectance measurement) and PVM (particle vision measurement). In this way, relationships between fine particles and metastable-form dissolution, and also between coarse particles and stable-form crystallization, could be defined. The different polymorphs were identified by Raman spectroscopy. FBRM provided a method for independently verifying these observations. PVM, in turn, verified the data interpretation strategy employed for FBRM. 

Fig. 6 Summary of data interpretation strategy (described in main text) for extracting viscoelastic parameters from film-loaded TSM resonator frequency response. Input parameters (at left of diagram) are resonator impedance and any selected parameter representative of film thickness (here, charge, interpreted using Faraday s law). Upper part of the scheme relates to acoustically thin films (yielding hf and pf). Lower part of diagram relates to acoustically thick films (yielding, with the help of hf and pf, G and C"). (Reproduced from Ref. [24] with permission from the American Chemical Society.)...

American TiKMacic Society, 1991, Lung Function Testing Selection of Reference Values and Interpretive Strategies, Am. Rev. Respir. Dis., 144(5) 1202-1218. 

J.R. Torres Lapasio, R.M. Villanueva Camanas, J.M. Sanchis Mallols, M.J. Medina Hernandez and M.C. Garcia Alvarez-Coque, Interpretive Strategy for Optimization of Surfactant and Alcohol Concentration in MLC, J. Chromatogr. A, 677 239 (1994). 

Statements can be developed using operators such as for all (V) and there exists (3) and combining such operators can provide a modular, precise, and abstract representation of interpretation strategies. Eor example, the interpretation of a X-ray fluorescence (XRE) spectrum could include the statement. 

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