Internal elastic lamina

The normal arterial wall consists of the intima, media, and adventitia, as illustrated in Fig. 4—3A. The endothelium is located in the intima and consists of a layer of endothelial cells that line the lumen of the artery and form a selective barrier between the vessel wall and blood contents. The internal elastic lamina separates the intima and media, where vascular smooth muscle cells are found. The vascular adventitia comprises the artery s outer layer. Atherosclerotic lesions form in the subendothelial space between the endothelial cells and internal elastic lamina. 

Figure 9.3 Inhibition of intimal hyperplasia by resveratrol in rabbits subjected to endothelial injury by denudation. Groups of eight New Zealand white rabbits, weighting 2.2 to 3.6 kg, were assigned randomly to control (untreated) (M), low (2 mg/kg/d) (L), and high dose (4 mg/kg/d) (H) resveratrol treatment, which was administered intragastrically for 5 weeks beginning 1 week before surgery. A 2-cm segment of injured iliac artery was excised, fixed in 4% paraformalin, embedded in paraffin, and sectioned at5-mm intervals from the proximal to the distal end. Representative sections were stained with hematoxylin/eosin. The external and internal elastic lamina were manually identified. Intimal proliferation index (IPI) was defined as the ratio of intimal area to [intimal+medial] area relative luminal area (RLA) was defined as the ratio of luminal area to [luminal+intimal+medial] area.

Figure 6 Effect of D-BSA, a diazeniumdiolated bovine serum albumin derivative, in promoting healing of balloon-injured pig coronary arteries. Shown are representative cross-sections of arteries taken two weeks after angioplasty from pigs dosed immediately before 30% balloon overstretch via intrapericardial instillation with 400 mg of underivatized BSA (a), 40 mg of D-BSA ( >), and 400 mg of D-BSA (c). Arrows denote ruptured ends of the internal elastic lamina for each vessel shown. [Reprinted from Reference 8 with permission.]... 

The normal artery wall is composed of three layers intima, media, and adventita (Figure 20-10). On the luminal side, the intima contains a single layer of endothelial cells. These cells permit passage of water and other substances from blood into tissue cells. On the peripheral side, the intimal layer is surrounded by a fenestrated sheet of elastic fibers (the internal elastic lamina). The middle portion of the intimal layer contains various extracellular components of connective tissue matrix and fibers and occasional smooth cells, depending on the type of artery, and the age and sex of the subject. 

Healed lesions—nodular fibrosis and loss of internal elastic lamina... 

The normal artery is composed of three distinct layers (Fig. 34.21). That which is closest to the lumen of the vessel, the intima, is lined by a monolayer of endothelial cells that are bathed by the circulating blood. Just beneath these specialized cells lies the subintimal extracellular matrix, in which some vascular smooth muscle cells are embedded (the subintimal space). The middle layer, known as the tunica media, is separated from the intima by the internal elastic lamina. The tunica media contains lamellae of smooth muscle cells surrounded by an elastin- and collagen-rich matrix. The external elastic lamina forms the border between the tunica media and the outermost layer, the adventitia. This layer contains nerve fibers and mast cells. It is the origin of the vasa vasorum, which supply blood to the outer two thirds of the tunica media. 

Wall morphology Complete tunica adventitia, external elastic lamina, tunica media, internal elastic lamina, tunica intima. ... 

A well-developed endothelium, subendothelium, and internal elastic lamina, plus about two to three 15 /rm thick concentric layers forming just a very thin tunica media no external elastic lamina)... 

Wall morphology More than one smooth muscle layer (with nerve association in the outermost muscle layer), a well-developed internal elastic lamina gradually thinning in 25- to 50 /rm vessels to a single layer of smooth muscle tissue, connective tissue, and scant supporting tissue Metarterioles 238,878,720 10 5/rm 0.1-1.8mm 5-15 um 41.6 ml 157,306,536 4.0 ml... 

A well developed endothehum, subendothelium, and internal elastic lamina well-developed tunica media but fewer elastic fibers than... 

Complete tunica adventitia, external elastic lamina, tunica media, internal elastic lamina, tunica intima, subendothelium, endothelium, and vasa vasorum vascular supply Main branches 32 5 mm-2.25 cm 3.3-6 cm —2 mm 83.2 ml... 

In Apo E-KO mice. All treatment accelerated atherosclerosis in the carotid artery, increased blood pressure, increased arterial stiffening, increased pulse wave velocity, and decreased arterial elasticity. These functional changes were correlated with morphological and biochemical changes as demonstrated by an increase in collagen content, a decrease in elastin content, and breaks in the internal elastic lamina in the aortic wall. In addition, endothelium-independent vasorelaxation to sodium nitroprusside was impaired (265). 

Internal elastic lamina, 1-9 Internal fixation biomaterials application in, 45-3... 

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