Dopamine interactions

Gudelsky, G.A. and Nash, J.F., Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine implications for serotonin-dopamine interactions, J. Neurochem. 66(1), 243-249, 1996. 

Bankson, M.G. and Cunningham, K.A., 3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions, J. Pharmacol. Exp. Ther. 297(3), 846-852, 2001. 

Ferre S, Fuxe K, Von Euler G, Johansson B, Fredholm BB (1992) Adenosine-dopamine interactions in the brain. Neuroscience 51 501-512... 

Kapur S, Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry 1996 153(4) 466-476. 

Probably the greatest advances in psychiatric medications of the last 15 years have involved the neurotransmitter serotonin. First was the arrival of serotonin-specific antidepressants with fewer side effects and greater safety than their predecessors. More recently, atypical antipsychotics have highlighted the importance of serotonin-dopamine interactions in the optimal treatment of schizophrenia and other psychotic disorders. While these are indeed significant advances, medications that alter serotonin activity are not without their own side effect burden. 

Kirch DC, Alho AM, Wyatt RJ Hypothesis a nicotine-dopamine interaction hnking smoking with Parkinson s disease and tardive dyskinesia. Cell Mol Neurobiol 8 285-291, 1988... 

Scsack, Susan R., and Virginia M. Picket. 1992. "Dual Ultrastructural Localization of Enkephalin and Tyrosine Hydroxylase Immunoreactivity in the Rat Ventral Tegmental Area Multiple Substrates for Opiate-Dopamine Interactions." Journal of Neuroscience 12 1335-50. 

As with Thorazine, this discovery was both serendipitous and perspicacious. And, as with Thorazine, LSD s mechanism of action turned out to be related to the neuromodulators. In this case it was serotonin that was blocked, but dopamine transmission was also affected. The prominent effect on dopamine was activation. Recent work on serotonin-dopamine interaction suggests that serotonin may inhibit dopamine function such that a decrease in serotonin efficacy leads indirectly to dopamine enhancement. This combination of serotonin blockade and dopaminergic enhancement is interesting because it mimics the chemistry of REM sleep in which normal dreaming occurs. 

What is an atypical antipsychotic From a pharmacological perspective, the atypical antipsychotics as a class may be defined in part as serotonin-dopamine antagonists (SDAs) (Fig. 11 — 16). Several other distinguishing pharmacological characteristics will be discussed in the following section. In this section, we will first discuss how the atypical antipsychotics all derive some of their atypical clinical properties from exploiting the different ways that serotonin and dopamine interact within the four key dopamine pathways in the brain. Thus, it is very important to understand serotonin-dopamine interactions in each of the four dopamine pathways. 

FIGURE 11—17. Serotonin-dopamine interactions in the nigrostriatal dopamine pathway. Serotonin inhibits dopamine release, both at the level of dopamine cell bodies in the brainstem substantia nigra and at the level of the axon terminals in the basal ganglia—neostriatum (see also Figs. 11 — 18 through 11 —20). In both cases, the release of serotonin acts as a brake on dopamine release. 

Buttarelli, F.R., Pontieri, F.E., Margotta, V. and Palladini, C. (2000) Acetylcholine/dopamine interaction in pla-naria. Comparative Biochemistry and Physiology C 1 25, 225-231. 

Since cholecystokinin peptides show a neuroleptic-like profile in several screening tests for neuroleptics, cholecystokinin-dopamine interactions are of interest, especially the modulation of cholecystokinin release by dopamine receptors (Table 1). In the rat striatum both Di and D2 receptor activation was reported to increase, and both Di and D2 receptor blockade to depress, the release of the peptide. 

Serotonin and Dopamine Interactions in Rodents and Primates Implications for Psychosis and Antipsychotic Drug Development... 

Does Dopamine Interact with Beta- or AlPha-adrenergic receptors ... 

Aalto S, Ihalainen J, Hirvonen J, Kajander J, Scheinin H. 2005. Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man. Psychopharmacology 182 375-383. 

Sesack SR, Carr DB, Omelchenko N, Pinto A. 2003. Anatomical substrates for glutamate-dopamine interactions, evidence for specificity of connections and extrasynaptic actions. Ann. N.Y. Acad. Sci. 1003 36-52. 

Binder EB, Kinkead B, Owens MJ, Nemeroff CB (2001) Neurotensin and dopamine interactions. Phamracol Rev 55 453-486. 

Le vite M, Chowers Y, Ganor Y, Besser M, Herslikovits R, Calialon L (2001) Dopamine interacts directly widi its D3 and D2 receptors on iionnal human T cells, and acdvates betal integiin funcdon. Eur J Immunol 31 3504—3512. 

Conformational isomerism is believed to be of great significance for drug-receptor and drug-enzyme interactions. For example, experimental data suggest that catecholamines such as norepinephrine and dopamine interact with their receptors in the antiperiplanar conformation. Furthermore, the preferred (pharmaco-phoric) conformation of acetylcholine at its muscarinic receptor sites is the synclinal conformer (Fig. 19). 

Ferre S, O Connor WT, Fuxe K, Ungerstedt U (1993) The striopallidal neuron a main locus for adenosine-dopamine interactions in the brain. J. Neurosci, 13, 5402-5406. 

Therapeutic Impeications oe Cannabinoid-Dopamine Interactions in the Basae Gangeia... 

Meschler JP Conley TJ, Howlett AC. Cannabinoid and dopamine interaction in rodent brain effects on locomotor activity. Pharmacol. Biochem. Behav. 67, 567-573 (2000). 

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