Integration of Databases

One attempt to quantify the overlap and complementarity between a number of public and commercial databases (at least at a structural level) was reported by 

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The integration of database development and integration of material properties discoveries must lead to a set of industrial standards and protocols that will provide... 

Below we will examine in more detail different methods of integration of databases of compounds and their reactions, having in mind mainly the case of large and very large databases. 

Establish the data dictionaries and entity-relationship models of relational databases as well as the classes and structure of object-oriented databases. Information Management is most often concerned with the integration of databases, requirements management tools, and any computer-generated media such as interactive training manuals, websites, intranets, and any other forms of media that trace the history of system information throughout the project life cycle. 

A strict separation of these three types of databases is difficult hence most databases contain a mixture of data types. Therefore the classification given here is based on the predominating data type. For example, the major emphasis of a patent database is on hterature, whereas it also comprises numeric and structural data. Another type is the integrated database, which provides a supplement of additional information, especially bibhographic data. Thus, different database types are merged, a textual database and one or more factual databases. 

Entrez (http //www.ncbi.nih.gov/entrez), information retrieval system, integrating NCBI databases of protein and nucleotide sequences, genomes, macromolecular stmctures, and MEDLINE literature database. 

Immunoglobulins and T-cell receptors (hie name Immuno.dat) Most REM-TrEMBL entries are immunoglobulins and T-cell receptors. The integration of additional immunoglobulins and T-cell receptors into SWISS-PROT has been stopped, because SWISS-PROT does not want to add all known somatic recombined variations of these proteins to the database. Currently there are more than 18,000 immunoglobulins and T-cell receptors in REM-TrEMBL. SWISS-PROT plans to create a specialized database dealing with these sequences as another supplement to SWISS-PROT but will keep only a representative cross section of these proteins in SWISS-PROT. 

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