Insulin release, effect

Insulin-releasing effectiveness Reduced Retained (mostly)... 

AIII (triterpene saponin) (Liliaceae) [rhizome] insulin release effect) (STZ-DB mouse) [gluco neogenesis, glycogenolysis]... 

The insulin-releasing effect of imidazolines would take place selectively via the clonidine-preferring site [109]. 

The insulin-releasing effect of sulphonylureas is thought to result from the closing of an ATP-dependent channel in the yff-cell plasma membrane. The decrease in permeability leads to a depolarization of the membrane and activation of Ca " channels. Calcium then enters the cell and activates an effector system for the release of insulin [9, 158]. The receptor for the sulphonylureas is believed to be a part of the ATP-dependent channel or... 

MTP-3115 (93), a close derivative of MTP-1307 (92), also improves glucose tolerance in normal and diabetic mice, but unlike the two previous compounds MTP-3115 also lowers blood glucose levels in fed and fasted animals, both normal and insulin-resistant. Since insulin secretagogues do not normally have an effect in insulin-resistant models, MTP-3115 is likely to exert its hypoglycaemic effect by a different mechanism [398], although an insulin releasing effect has been reported [399]. 

The insulin releasing activity of the sulfonylureas has been studied extensively and differs in important respects from that of glucose. Mannoheptulose and diazoxide do not inhibit the insulin releasing effect of the sulfonylureas although they both block glucose induced insulin secretion.9,19... 

The insulin releasing effect of amino acids has been thoroughly reviewed.20 Many, but not all, amino acids stimulate insulin secretion to some extent. Arginine, because it is the most potent, has been studied extensively. The action of leucine differs sufficiently from that of the other amino acids that it appears to function by a different mechanism. Arginine is a potent stimulator of insulin secretion in the normal pancreas... 

Henquin J-C. 1980. Specificity of divalent cation requirement for insulin release Effects of strontium. Pflugers Arch(Eur J Physiol) 383 123-129. 

A recent report attempts to dissect the hypoglycemic effects and Insulin releasing effects of tolbutamide by comparing the activity of its metabolites hydrox3nnethyltolbutamlde and carboxytolbutamide. Related effects have been seen with cortlcotrophin A, and its N-acetyl deriva-tlvel 2,143,... 

Insulin release by ketone bodies would provide a most elegant feedback mechanism by which ketosis could normalize its own level by stimulating glucose usage. Yet, although an insulin-releasing effect has been claimed when j -hydrobutyric acid and acetoace-tate are administered in vivo, in vitro ketone bodies inhibit insulin release. 

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