Insulin pancreozymin

Other factors known to influence insulin release include the gut hormones secretin, pancreozymin and gastrin50 53. Of these, secretin seems to be most important since at physiological levels it may act as a priming agent to enhance the initial phase of insulin release. 

Glucagon is believed to stimulate insulin secretion in man. Secretin, pancreozymin, and gastrin have all been found to stimulate insulin release. Acetylcholine and carbamylcholine stimulate insulin secretion in vitro in contrast, epinephrine and norepinephrine inhibit it. Thus, in pheochromocytoma, acute insulin responses are inhibited. 

We have previously demonstrated stimulation of increments in blood insulin concentration with crude and purified preparations of porcine secretin (ll, 12). We report here further investigation of the effects of hormones known to regulate digestive secretions, on the endocrine response of the pancreas to the intravenous administration of glucose or arginine in man. These studies have been carried out with preparations of porcine secretin and pancreozymin of high specific activity, supplied by... 

Pancreozymins, obtained from "Karolinska Institute", Stockholm, was effective in concentrations of 1,5 and 10 u/ml on pieces of rabbit pancreas (Fig.12). Pancreozymins, obtained from "Boots", England, in concentrations of 1 U/ml, produced increases in insulin output similar to those obtained by the same concentration of pancreozyraine "Karolinska".Following incubation with 5 U of the British preparation/... 

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