Instrument Detection Limit IDL

How do you distinguish between the instrument detection limit (IDL) and the method detection limit (MDL) ... 

The method detection limit (MDL) is the smallest quantity or concentration of a substance that a particular instrument can measure (Patnaik, 2004). It is related to the instrument detection limit (IDL), which depends on the type of instrument and its sensitivity, and on the physical and chemical properties of the test substance. 

Table 4.4 compares the sensitivities of various elemental analysis techniques based on instrument detection limits (IDLs). 

The concentration of analytes that can be measured in various materials has been decreasing over the years as sensitivity and detection limits of analytical techniques have improved. The method detection limit (MDL) is the order of magnitude of the smallest quantity or concentration of substance which can be detected in principle the limit of detection (LOD), on the contrary, is a precisely calculable statistical value for a particular, defined analytical procedure. The instrument detection limit (IDL) is the smallest signal above background noise that an instrument can detect reliably. It is expressed either as an absolute limit (in units of mass, eg, ng), or as a relative limit (in terms of concentration, eg, g mL 1). 

LOQ) will typically be higher than the instrumental detection limit (IDL), because of background analyte and matrix-based interferences. The BEC (blank equivalent concentration) used in Table 4.7 is the apparent concentration of an analyte normally derived from intercepted point of its calibration curve or by reference of the actual counts for that analyte in a blank solution. The BEC gives a good indication of the blank level, which will affect the IDL. Most often, the detection limits are calculated as three times the normal standard deviation of the BEC in a within batch replicate analytical measurement of a blank solution. Therefore, if the instrument is stable enough, this will give a better IDL than the BEC itself. The BEC is a combination of the contamination of the analyte in the solution, the residual amount of the analyte in the spectrometer and the contribution of any polyatomic species in the analyte mass. 

Instrument Detection Limits (IDL, pg) Obtained and the Three Most Abundant Fragment Ions of Compounds IDL with GC/EI/MS, Molecular Weight M ), Selected OCRs m/z ... 

The use of atomic fluorescence for the determination of mercury was first reported by Thomson and Reynolds in 1971 [2]. Since then, several authors [3-6] have described enhancements to the technique that have reduced formal instrument detection limits (IDL) for the fluorescence technique to the 1-10 ng/1 range. Knox et al. [7] report on the use of atomic fluorescence detection limit for mercury to less than 1 ng/1. A European standard EN 13506 was published in 2001. This uses vapor generation coupled to direct atomic fluorescence measurement. The most recent version of the US EPA standard 1631 utilizes an additional gold amalgamation step. The amalgamation provides the potential for an additional order of sensitivity but also requires considerable attention to detail and cleanliness to avoid contamination. 

Limit of Detection fLODl. "The limit of detection (1X)D) is defined as the lowest concentration level that can be determined to be statistically different from a blank. The concept is reviewed in [ref. 38) together with the statistical basis for its evaluation. Additional concepts include method detection limit (MDL), which refers to the lowest concentration of analyte that a method can detect reliably in either a sample or blank, and the Instrument detection limit (IDL), which refers to the smallest signal above background noise that an Instrument can detect reliably. Sometimes, the IDL and LOD are operationally the same. In practice, an indication of whether an analyte is detected by an Instrument is sometimes based on the extent of which the analyte signal exceeds peak-to-peak noise" (16). 

Instrumental detection limit (IDL) protocols are used to determine when an analog signal is sufficiently different from the background noise to conclude that a measureable "real" signal has been observed. But IDL terminology and estimation protocols are not standard. 

Instrument detection limits (IDLs) for most metals by FIAA are in the low-ppm realm in contrast to graphite furnace AA (GFAA). The conventional premixed chamber-type nebulizer burner is common. The sample is drawn up through the capillary by the decreased pressure created by the expanding oxidant gas at the end of the capillary, and a spray of fine droplets is formed. The droplets are turbulently mixed with additional oxidant and fuel and pass into the burner head and the flame. Large droplets deposit and pass down the drain 85-90% of the sample is discarded in this way. Figures 10-15 in Ref. 2 (pp. 216-218) provides a good schematic of the laminar flow burner. 

Instrument detection limit (IDL) A term utilized in the EPA Inorganic Contract Laboratory Program. The IDL is three times the standard deviation obtained for the analysis of a standard solution (each analyte in reagent water) at a concentration of three to five times that of the IDL on three nonconsecutive days with seven consecutive measurements per day. 

Table 2 Recommended wavelengths and estimated instrumental detection limits (IDLs) for radial view ICP/AES [2]...

In Table 2 the wavelengths and instrumental detection limits (IDLs) of elements for ICP-AES are listed. And in Table 4, elements and measured mass numbers are listed for ICP-MS. For example, Cu has a mass number of 63 and 65. This list shows that the peak for mass number 63 is better than that of 65 to detect the intensity of Cu, because the existence of Cu is three times higher than that of Cu. 

The approach described in Lee Aizawa (2003) consists of two steps for the determination of the LOD and LOQ. These firstly involve determination of the Instrumental Detection Limit (IDL) and Instrumental Quantification Limit (IQL), and using these values to estimate the Method Detection Limit (MDL) and Method Quantification Limit (MQL), following calculation of the LOD and LOQ for the extraction/analysis method. 

The predicted instrumental detection limit (IDL, cl) is calculated as follows ... 

The LODs can be represented in three different forms depending upon the requirements. The three representations are (1) the instrument detection limit (IDL), (2) the method detection limit (MDL), and (3) the practical detection limit (PDL). 

There are other approaches used for calculating LODs it is important to specify exactly how an LOD has been determined. An LOD can be defined by the instrument (e.g., using pure water) this would be the instrument detection limit (IDL). One can be defined for an entire analytical... 

An important distinction to be kept in mind is that between the instrumental detection limit (IDL) and the method detection limit (MDL) the IDL refers to an LOD determined using clean solutions of the analytical standard injected into the analytical instrument (e.g., LC-MS, GC-MS/MS) operated under stated conditions, while the MDL involves blank matrix samples spiked with known amounts of the calibration standard and taken through the entire extraction-cleanup-analysis procedure. This distinction is irrelevant to the question of how either of these LOD quantities is to be defined and measured (see below). 

Instrumental detection limit (IDL) Refers to an LOD determined using clean solutions of the analytical standard injected into the analytical instrument operated under stated conditions. 

Instrument detection limit (IDL) Prepare 10 separate calibration blanks. Analyze the 10 blanks in triplicate on three nonconsecutive days, for each analyte. The IDL is equal to three times the standard deviation of the 10 blank measurement results, expressed as pg/L. 

The variance of peak areas from consecutive measurements also shows all noise influences for each injection, the overall precision of the measurement expressed in the relative standard deviation (%RSD) (Glaser et al., 1981). The theoretical instrument detection limit (IDL) can be calculated from the peak variance of a series of measurements. In these cases, the Student f-distribution is used to calculate the... 

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