Inositol phospholipid, metabolism

Lynch M. A. and Voss K. L. (1990). Arachidonic acid increases inositol phospholipid metabolism and glutamate release in synaptosomes prepared from hippocampal tissue. J. Neurochem. 55 215-221. 

Fig. 4. Proposed production of a glycan-inositol phosphate mediator by insulin. This summarizes Sal-tiel and Cuatrecasas concept for the production of novel mediators through insulin s action. It may, by analogy with the receptor-mediated stimulation of inositol phospholipid metabolism, involve a G-pro-tein. Here it is postulated that the putative Glns may play such a role.

There is now considerable evidence to suggest that hormones which stimulate inositol phospholipid metabolism do so through a distinct G-protein [90-92]. It is thus possible that insulin might activate a G-protein in order to stimulate the proposed phosphatidylinositol-specific phospholipase C claimed to produce the GIPs insulin mediator (Fig. 4). 

Mueller-Roeber, B., and Pical, C., 2002, Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C. Plant Physiol. 130 22—46. 

It is not mediated by an increase in intracellular calcium concentrations or by inositol phospholipid metabolism. 

Leeb-Lundberg LM, Cotecchia S, DeBlasi A, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of a -adrenergic receptors coupled to inositol phospholipid metabolism in DDT1MF-2 smooth muscle cells. J Biol Chem 1987 262 3098-3105. 

Nicoletti. F., Meek, J.L., ladarola, M.J., Chuang, D.M., Roth, B.L., Costa. E., 1986. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. J. Neu-rochem. 46, 40-46. 

It is now generally accepted that both of the products of phosphatidylinositol 4,5-bisphosphate hydrolysis can function as intracellular second messengers. 1,2-Diacylglycerol can affect a variety of intracellular processes by activation of protein kinase C [ 148, 229, 230]. Inositol 1,4,5-trisphosphate, on the other hand, has been shown to release calcium ions from non-mitochondrial stores in a number of peripheral tissues and may thus be the link between the receptor and the intracellular calcium store in many pharmacological responses [231-233]. Furthermore, it remains a possibility that inositol phospholipid hydrolysis may also have a r61e in calcium gating [221,234]. If inositol phospholipid metabolism is closely coupled to receptor-mediated calcium mobilization, then this response may be a more general consequence of H,-receptor stimulation than other H,-responses. 

Arguably the most rapidly expanding area of research in biological phosphate chemistry over the past two or three years has been in the area of inositol phosphates. Agonist-induced stimulation of inositol-phospholipid metabolism results in hydrolysis of phosphatidyl inositol 4,5-bisphosphate... 

Takenawa, T., Ishitoya, J. and Nagai, Y. (1986). Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils. ]. Biol Chem., 261, 1092-1098... 

Kuksis A (2003) Inositol Phospholipid Metabolism and Phosphatidylinositol Kinases, vol. 30. Laboratory Techniques in Biochemistry and Molecular Biology. Amsterdam Elsevier Science Publishers. 

Changes in inositol phospholipids had been shown to occur in plant cells as a result of different stress (1). We decided to study the inositol phospholipid metabolism in suspension cultured Tobacco cells because they provide a relatively uniform system to which a stress might be easily applied. 

Quarmby LM, Yueh YG, Cheshire JL, Keller LR, Snell WJ, Crain RC. Inositol phospholipid metabolism may trigger flagellar excision in Chlamidomonas reinhardtii, J Cell Biol 1992 116 737-744. 

An interesting case of synaptic modulation that may depend upon arachidonate stimulation of PKC activity has been reported by Immaculada Herrero, Jose Sanchez-Prieto and their coworkers at the Universidad Complutense in Madrid.Glutamatergic nerve terminals isolated from the rat brain express a metabotropic sub-type of the glutamate receptor that is coupled to inositol phospholipid metabolism and PKC activation. Stimulation of nerve... 

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