Injectable composites hydrogels

StmiUon, X., et al., 2011. Treatment of periodontal defects in dogs using an injectable composite hydrogel/biphasic calcium phosphate. J. Mater. Sci. Mater. Med. 22 (7), 1707-1717. Available at http //www.ncbi.nhn.nih.gov/pubmed/21611794 (accessed 05.01.16). 

In this study, we prepared a new kind of biodegradable and injectable composite hydrogel based on PECE and Pluronic FI27 copolymer. The eomposite hydrogels are free-flowing sol... 

Sahu A, Choi Wl, Tae G. A stimuH-sensitive injectable graphene oxide composite hydrogel. Chem Commun (Camb). 48(47) (2012) 5820-5822. 

Park, H., Temenoff, J. S., Tabata, Y., Caplan, A. I. Mikos, A. G. (2007) Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials, 28, 3217-27. 

In vivo gel formation and degradation tests were performed in BALB/c mice (20 2g). The composite hydrogel (SI, S2, S3, S4 and S5) at concentration of 30wt% were prepared. Then, each animal was subcutaneously injected with 0.5 mL of composite hydrogel solutions by a syringe with a 25 gauge needle. At predetermined time (2h, 6h, Id, 3d, 7d, lOd, and 14d), the animals were sacrificed by cervical dislocation. And then the injection site was carefully cut open and the in situ formed gel was taken photo. 

Figure 8. In situ gel formation and degradation behavior of composite hydrogels. From A to E showed the photograph took at Id, 3d, 7d, lOd and 14d after injection respectively (From left to right S4, S3, S2 and SI). F and G presented the photograph took at 2h and 6h after Pluronic FI27 hydrogel injection.

Figure 9. Photograph of tissue samples from injection site after composite hydrogel injection for 14d ( X 400). A Control group B S3 hydrogel injection group C S1 hydrogel injection group.

Sahu, A., Choi, W.I., Tae, G., 2012. A stimuh-sensitive injectable graphene oxide composite hydrogel. Chemical Communications 48, 5820—5822. 

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