Inhibitory effect of chitosan

F ig. 3. Inhibitory effect of chitosan on gastro intestinal toxicity... 

Fig. (55). Inhibitory effects of chitosan on Fig. (56). Inhibitory effects of chitosan on...

FIGURE 15.1 Inhibitory effect of chitosan-starch solution against (a) E. coli, (b) S. aureus, and (c) B. subtilis. (From Tripathi, S. et ah, Asian Chitin J., 4, 29, 2008a. With permission.)... 

Guminska, M., Ignacak, J., and Wojcik, E. 1996. In vitro inhibitory effect of chitosan and its degradation products on energy metahohsm in Ehrhch ascites tumoiu cells (EAT). Pol. J. Pharmacol., 48 495-501. 

These results suggest that the inhibitory effects of chitin-chitosan on pancreatic lipase activity may be mediated by the interaction between substrate and enzyme through lecithin. Moreover, as shown in Table 4,... 

Fujiwara, M., Hayashi, Y., and Ohara, N. 2004. Inhibitory effect of water-soluble chitosan on growth of... 

Chitosan NPs Delivery of (Inhibitory effects) of trolox on tert-butyl hydroperoxide induced RAW264.7 apoptosis [296]... 

Lu H, et al. Inhibitory effects of trolox-encapsulated chitosan nanoparticles on tert-butylhydroperoxide induced RAW264.7 apoptosis. Biomaterials. 2012 33(33) 8517-28. 

Takahashi, T., Imaia, M., Suzukia, I., and Sawai, J. (2008). Growth inhibitory effect on bacteria of chitosan membranes regulated by the deacetylation degree. Biochem. Eng.. 40, 485-491. 

It is well known that dietary fat is not absorbed from the intestine unless it has been subjected to the action of pancreatic lipase [1], Previously, we found that basic proteins such as protamines, histones and purothionine inhibited the hydrolysis of triolein emulsified with phosphatidylcholine [2], The inhibition of hydrolysis of dietary fat may cause a decrease or delay in the intestinal absorption of fat and reduce blood chylomicron levels, an excess of which is known to induce obesity [3], Therefore, there was a possibility that inhibitory substances toward pancreatic lipase activity may prevent the onset of obesity induced by feeding a high fat diet to mice. Recently, we found that natural products such as tea saponin, platycodi radix saponin, chitin-chitosan and chondroitin sulfate inhibited the pancreatic lipase activity. In the following section, the anti-obesity effects of these natural products will be described in detail. 

A comparison of the antibacterial activity of normal chitosan, nanochitosan, and silver-loaded nanochitosan applied on woven polyester fabrics showed that the nanoparticle form of chitosan imparted much enhanced antibacterial activity, as indicated by a reduction in minimum inhibitory concentration (MIC) from 0.5% to 0.01% (Wazed Ali et al., 2011). The silver-loaded chitosan nanoparticle showed a further increase in activity (MIC 0.001%) due to the synergistic effect of Ag and chitosan nanoparticles. These particles additionally show a release mechanism as evident from a clear zone of inhibition (Figure 5.4(a—d)). 

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