Inhibitors, spleen tyrosine kinase

Spleen Tyrosine Kinase (Syk) Biology, Inhibitors and Therapeutic Applications... 

A series of novel 1,6-naphtyridine derivatives were prepared as potential inhibitors of human topoisomerase I (2003JMC2254), farnesyltransferase inhibitors (2003USP2003199544), p38 mitogen-activated protein kinase inhibitors (2003MI7), SYK kinase inhibitors (2003PIAW02003057695) and spleen tyrosine kinase inhibitors (2003MI8). 

Zhu Y, Herlaar E, Masuda ES, Burleson GR, Nelson AJ, Grossbard EB, Clemens GR. Immunotoxicity assessment for the novel spleen tyrosine kinase inhibitor R406. Toxicol Appl Pharmacol 2007 221 268-277. 

Spleen tyrosine kinase Allergic rhinitis, anaphylaxis, and asthma DS CATALYST Six inhibitors showed good in vitro potency [130]... 

Dasatinib, the Abl-antagonist tyrosine kinase inhibitor, suppressed adhesion-mediated respiratory burst and superoxide release of neutrophil leukocytes antagonized the leukocytes immune complex-induced activation, and their migration toward fibrinogen-coated substrate, but it did not block LPS- or TNF signaling, stimulation by zymosan, and phagocytosis. Dasatinib blocked Syk activation (spleen tyrosine kinase, agonist of Fey receptors) [2215] (Table XXVI). 

Discovery and development of spleen tyrosine kinase inhibitors 12JMC 3614. 

Scott DL (2011) Role of spleen tyrosine kinase inhibitors in the management of rheumatoid arthritis. Drugs 71 1121-1132... 

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