Tyrosine kinase antagonists

VEGF receptor blockers Small receptor tyrosine kinase antagonists... 

I. VEGF Receptor Tyrosine Kinase Antagonist Assay... 

VEGF receptor tyrosine kinase antagonist assay was performed according to the method of Shibuya (1). Testing results are provided in Table 3. 

Table 3 Effectiveness of selected experimental agents as Flt-1 VEGF receptor tyrosine kinase antagonists. IC50 values above 0.01 p,M are preferred...

Additional benzamide VEGF receptor tyrosine kinase antagonists prepared by the authors (2) in an earlier investigation are summarized in Table 4. 

Andrews (3) and Tang (4) prepared VEGF receptor tyrosine kinase antagonists consisting of l,3-dihydro-2H-indol-2-one derivatives, (I) and (II), respectively, which were effective as abnormal cell proliferation inhibitors. 

Mr 305.33, cryst., mp. 218-219 C, -232 C, [a] +44.3° (CH3OH). An alkaloid from leaves, stems, and bark of Amoora rohituka and Dys-oxylum binectariferum (Meliaceae) with anti-inflammatory and immunomodulatory activity, lead structure for cancer therapeutics e.g. the developmental product flavopiridol (tyrosine kinase antagonist). 

Antagonists of Receptor Tyrosine Kinases Enhance Therapeutic Response to Radiation Endothelial Repair Gene Therapy Approach to Angiolytic and Angiostatic Therapy in Cancer References... 

ANTAGONISTS OF RECEPTOR TYROSINE KINASES ENHANCE THERAPEUTIC RESPONSE TO RADIATION... 

Molecules that prevent a response from receptors are called antagonists. Sometimes antagonists for tyrosine kinase-linked receptors are called inhibitors. Why is this appropriate ... 

---