Inhibitors recombinant

And finally, whilst this chapter focuses on CYP enzymes, the same principles can be applied to any enzyme or transporter providing the tools to do the job are available (e.g., in silica models, specific substrates/inhibitors, recombinant systems). 

Vlasuk GP, Bradbury A, Lopes-Kinninger L, Colon S, Bergum PW, Maki S, Rote WE. Pharmacokinetics and anticoagulant properties of the factor Vila - tissue factor inhibitor recombinant nematode anticoagulant protein c2 following subcutaneous administration in man dependence on the stoichiometric binding to circulating factor X. Thromb Haemost 2003 90 803-12. 

Bivalirudin, reversible thrombin inhibitor, recombinant hirudin... 

Chemical Reactions Combinatorial Chemistry Equations, Chemical Equilibrium Inhibitors Recombinant DNA Synthesis, Chemical... 

Allergenic extracts Antitoxins, antivenoms, venoms Blood, blood components, plasma-derived products (e.g., albumin, immunoglobulins, clotting factors, fibrin sealants, proteinase inhibitors), recombinant and transgenic versions of plasma derivatives... 

There are many high-molecular-weight, polypeptide, elastase inhibitors which have been isolated from animal or plant sources. Most of these, the non-human proteins, would probably induce an immunogenic response and are not suitable for clinical development. However, a subset of these inhibitors, predominantly human in origin, is being explored as a source for clinically-useful elastase inhibitors. Each of the human compounds is found in a specific location, which probably is its primary site for inhibitory action. The physical properties of many of these natural inhibitors have been reported (see Table 2.i)[45-51]. Due to their size and other physical properties, only intravenous or topical formulations of the proteinaceous inhibitors have been considered for clinical use. The pharmacological studies have included natural inhibitors, recombinant variants (i.e. peptides with identical sequences to the natural inhibitors but not necessarily the same glycosylation) and recombinant mutants (peptides with unnatural sequences) [52],... 

It will be seen that very varied relations are to be expected according to the conditions of working, which affect the completeness of light absorption, the relative roles of reaction with inhibitors, recombination in the gas, diffusion to the walls, and so on. It is scarcely to be wondered at that before the problem was as well understood as it has now become in the light of the general study of chain reactions, many conflicting views were held, not only about the interpretation, but about the facts themselves. 

HMG CoA-Reductase HMG-CoA-Reductase Inhibitors Homologous Desensitization Homologous Proteins Homologous Recombination Homology Modeling Hormonal Contraceptives Hormone Replacement Therapy (HRT)... 

Hertogs K, de Bethune MP, Miller V, Ivens T, Schel P, Van Cauwenberge A, Van Den Eynde C, Van Gerwen V, Azijn H, Van Houtte M, Peelers F, Staszewski S, Conant M, Bloor S, Kemp S, Larder B, Pauwels R (1998) A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs. Antimicrob Agents Chemother 42 269-276... 

Zahedi R, Bissler J, Davis AR. Andreadis C. Wisnieski J Unique Cl inhibitor dysfunction in a kindred without angioedema. II. Identification of an Ala443 Val substitution and functional analysis 92 of the recombinant mutant protein. J Clin Invest 1995 95 1299-1305. 

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