Direct thrombin inhibitors recombinant hirudin derivatives

Pharmacology Lepirudin (rDNA), a recombinant hirudin derived from yeast cells, is a highly specific direct inhibitor of thrombin. 

Lepirudin is a recombinant derivative of hirudin (direct thrombin inhibitor secreted by salivary glands of leech). It inhibits thrombin directly and is mainly used in heparin induced thrombocytopenia. 

A. General description Bivalirudin, a 20 amino-acid synthetic peptide, is a direct thrombin inhibitor. It is an analogue of recombinant hirudin (Refludan), a 65 amino-acid anticoagulant derived from the leech. The molecular weight of bivalirudin is about 2.2kDa (anhydrous free base peptide). 

Hirudin is a direct thrombin inhibitor marketed in a recombinant form (lepirudin). It is a protein derived from a salivary gland of the medicinal leech. It binds tightly to exosite I and the apolar site near the catalytic site. It is used as a substitute for... 

Lepirudin (Refludan) is a recombinant derivative (Leu -Thr -63-desulfohirudin) of hirudin, a direct thrombin inhibitor present in the salivary glands of the medicinal leech. It is a 65-amino-acid polypeptide that binds tightly to both the catalytic site and the extended substrate recognition site (exosite I) of thrombin. Lepirudin is approved in the United States for treatment of patients... 

A. General description Lepirudin is a recombinant hirudin, a highly specific direct inhibitor of thrombin, derived from yeast cells. The polypeptide is composed of 65 amino acids and has a molecular weight of 7 kD. Natural hirudin is produced in trace amounts as a family of highly homologous isopolypeptides by the medicinal leech. Lepirudin is identical to natural hirudin except for the substitution of leucine for isoleucine at the N-terminal end... 

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