Anticoagulant protein

At this stage, patients may experience symptoms of acute coronary syndrome. If endogenous anticoagulant proteins fail to halt this process, platelet aggregation continues and fibrinogen is converted to fibrin, resulting in an occlusive thrombus (Panel F). 

Dahlback, A. and Villotreix, B. 2005. The anticoagulant protein C pathway. FEBS Letters 579(15), 3310-3316. 

Annexin V is a human placental anticoagulant protein of molecular weight 35kDa that binds to membranes and lipid bilayers containing phosphatidylserine in the presence of free calcium. Annexin V binding to cell surfaces said to result from transmembrane movement of... 

Thiagarajan, P. and Tait J.F., 1990, Binding of annexin V/placental anticoagulant protein 1 to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets. J. Biol. Chem., 265 17420-17423. 

Vlasuk GP, Bradbury A, Lopes-Kinninger L, Colon S, Bergum PW, Maki S, Rote WE. Pharmacokinetics and anticoagulant properties of the factor Vila - tissue factor inhibitor recombinant nematode anticoagulant protein c2 following subcutaneous administration in man dependence on the stoichiometric binding to circulating factor X. Thromb Haemost 2003 90 803-12. 

Revasc/Ciba- hirudin, anticoagulant protein Geigy frrxn medical leech Himdo... 

Morbidity and mortality in HIT are related to thrombotic events. Venous thrombosis occurs most commonly, but occlusion of peripheral or central arteries is not infrequent. If an indwelling catheter is present, the risk of thrombosis is increased in that extremity. Skin necrosis has been described, particularly in individuals treated with warfarin in the absence of a direct thrombin inhibitor, presumably due to acute depletion of the vitamin -dependent anticoagulant protein C occurring in the presence of high levels of procoagulant proteins and an active hypercoagulable state. 

Figure 12-17 Major components of the human blood clotting cascades. The site of action of the leech anticoagulant protein hirudin is also indicated.

The complex interaction of the factors described above, and a number of endogenous anticoagulant proteins such as protein C, protein S, and antithrombin III normally control the balance between clot formation and clot breakdown.36,61 Disease or inactivity, however, can alter this balance, leading to exaggerated clotting and venous or arterial thrombosis. Drugs used to treat overactive clotting are addressed in the next section. 

Jalbert LR, Rosen ED, Moons L et al. (1998) Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest 102 1481-1488... 

Widespread e.g. Vaccinium corymbosum (Ericaceae), Medicago saliva (alfalfa) (Fabaceae), Castaneasp. (chestnut) (Fagaceae) [leaf]), Triticum aestivum (Poaceae) Dihydro form (KH ) coenzyme for "y-carboxyglutamic acid formation on procoagulant factors II, VII, IX X, anticoagulant proteins C S, matrix Gla protein osteocalcin... 

Intestinal bacteria dihydro form (KH9) coenzyme for "y-carboxyglutamic acid formation on procagulant factors II, VII, IX X, anticoagulant proteins C S, matrix Gla protein osteocalcin... 

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