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Inhibitors, multiple uptake

Multiple sclerosis (MS) 4. In rats with EAE, an animal model of multiple sclerosis, AEA and 2-AG levels are decreased in the striatum and midbrain. This might be associated with motor impairment 4. Inhibitors of degradation (both FAAH and cellular re-uptake)... [Pg.467]

Sobin C, Sackeim HA, Prudic J, et al Predictors of retrograde amnesia following ECT. Am J Psychiatry 152 995-1001, 1995 Sogaard U, Michalow J, Butler B, et al A tolerance study of single and multiple dosing of the selective dopamine uptake inhibitor GBR 12909 in healthy subjects. Int Clin Psychopharmacol 5 237-251, 1990... [Pg.748]

Calcitonin is secreted by the parafollicular or C cells, which arise from the neural crest and are distributed throughout the thyroid gland. These cells are included in the APUD (cmine precursor uptake and decarboxylation) family, which explains the association of medullary thyroid carcinoma (a tumor of the C cells) and other tumors of the APUD family in multiple endocrine neoplasia type 2A and -2B (MEN-2A and MEN-2B). Release of calcitonin is stimulated by calcium, and it has been used pharmacologically as an inhibitor of bone resorption. [Pg.1926]

Cabranes A, Venderova K, de Lago E, Fezza F, Valenti M, Sdnchez A, Garcfa-Merino A, Ramos JA, Di Marzo V, Fernandez-Ruiz J (2005) Decreased endocannabinoid levels in the brain and beneficial effects of certain endocannabinoid uptake inhibitors in a rat model of multiple sclerosis involvement of vanilloid TRPV 1 receptors. Neurobiol Dis (in press)... [Pg.501]

The inhibitory effects of the pyrrolinone derivatives were evaluated using enzyme inhibition and cellular activation assays. Compound 6 (Fig. 4.3-5) showed an IC50 of 10 nM, compared to 0.6 nM for the related peptide inhibitor 5 (L682,679). However, the synthetic agent 6 showed better cell transport capacity. In a cellular antiviral assay, 5 and 6 showed CIC95 values (the concentration that inhibits 95% of virus multiplication in the cellular cultures) of 6.0 and 1.5 pM, respectively. Smith and Hirschmann proposed that the improved cellular uptake properties of polypyrrolinones are due to a reduction in the inhibitor solvation. Solvation is an impediment to transport because extraction of a molecule into a lipid bilayer from an aqueous phase is... [Pg.258]

Gustavson LE, Mengel HB. Pharmacokinetics of tiagabine, a y-aminobutyric acid-uptake inhibitor, in healthy subjects after single and multiple doses. Epilepsia 1995 36 605-611. [Pg.797]

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Inhibitors, multiple

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