Inhibitor binding plant

A series of mannosylated dendrimers have been prepared and evaluated for their biological properties, in particular as inhibitors of plant lectins.83 Subsequently, mannosylated PAMAM, and a dendrimer based on a 3,5-bis-(2-aminoethoxy)benzoic acid branching unit, have been tested for their ability to inhibit bacterial infection by interfering with the binding of uropathogenic... 

It was recognized that an acylphosphonate or acylphosphinate might act as an effective inhibitor against plant PDHc. Both compounds could compete with pymvate for the active site of plant PDHc El by binding with TPP resulting a TPP complex. It was speculate that, a highly reactive carbanion of TPP should nucleophiUcaUy attack carbonyl carbon atoms of 1-2 to readily form a phosphinic adduct which resembled normal reactive intermediate a-lactyl-TPP. Once it was bond, the normal decarboxylation process in plant was shut off and plant die as their... 

In addition to the aforementioned effects on paracellular drug transport, Ca2+ also plays an important role in the transcytosis of macromolecules. The entry of the plant lectins abrin, modeccin, and viscumin into Vero cells was inhibited in a Ca2+-free medium a well as in a Ca2+-containing medium containing verapamil and Co2+, both inhibitors of Ca2+ [217], Ca2+ is therefore required at a stage after the binding of the above lectins, perhaps in the fusion and exocytosis of membrane vesicles. 

Photosystem II inhibitors, 13 288-294 plant growth regulator synthesis and function inhibitors, 13 304—307 Herbicide analysis methods, 13 312—313 Herbicide atomizer, 23 197 Herbicide binding, polypeptide... 

A neolignan isolated by the Merck group from the plant Piperfutokadsurae, was the first natural product discovered as a potent inhibitor of the binding of [3H ]PAF to rabbit platelet membrane preparation with an IC50 close to 0.1 /iM [268]. Named kadsurenone (26), it was also shown to be a specific and potent inhibitor of PAF-induced rabbit platelet aggregation with an IC50 value of 0.99 juM. 

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